Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:INP4A_HUMAN
Description:inositol polyphosphate-4-phosphatase, type I, 107kDa [Source:HGNC Symbol;Acc:6074]
Location:chr2 q11.2
Node attribute:Enzyme(target); Enzyme(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y972PPEGTyGKVETPhosphoSitePlus
T942CRRENtMKNVGPhosphoSitePlus
S395EECCTsSGCQSPhosphoSitePlus
S916KYAFNsLQLKAHPRD
T22MQRAStIDVAAPhosphoSitePlus
T137LLGSGtFIVKDPhosphoSitePlus; HPRD
S252EQMAEsVLSLHPhosphoSitePlus
Y965AFPKHyRPPEGPhosphoSitePlus
Y481AARPDyIASKAPhosphoSitePlus
Y427KTQVSyYAERLPhosphoSitePlus
S21AMQRAsTIDVAPhosphoSitePlus
S433YAERLsRAAKDPhosphoSitePlus
S955KYAFNsLQLKAPhosphoSitePlus
T394FEECCtSSGCQPhosphoSitePlus
S487IASKAsPTSTEPhosphoSitePlus
S490KASPTsTEEEQPhosphoSitePlus
S851LPRSRsQTCLPPhosphoSitePlus
Y355GSDQNyDIVTIPhosphoSitePlus; phosphoELM

Dephosphorylation site
INP4A_HUMAN do not have dephosphorylation site.

Mutation site
INP4A_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000074304Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.2615169874

Hyperphosphorylation site
INP4A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
INP4A_HUMANINPP_HUMANenzyme catalysisKEGG
IMPA1_HUMANINP4A_HUMANenzyme catalysisKEGG
PTEN_HUMANINP4A_HUMANenzyme catalysisKEGG
INP4A_HUMANMTM1_HUMANenzyme catalysisKEGG
INP4A_HUMANFYV1_HUMANenzyme catalysisKEGG
PI3R5_HUMANINP4A_HUMANenzyme catalysisKEGG
INP4A_HUMANPI3R5_HUMANenzyme catalysisKEGG
INP4A_HUMANSHIP1_HUMANenzyme catalysisKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatasIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatasIEAmolecular_function
GO:0005829cytosolTAScellular_component


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