| UniProt/SwissProt ID: | INP4A_HUMAN |
| Description: | inositol polyphosphate-4-phosphatase, type I, 107kDa [Source:HGNC Symbol;Acc:6074] |
| Location: | chr2 q11.2 |
| Node attribute: | Enzyme(target); Enzyme(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y972 | PPEGTyGKVET | PhosphoSitePlus | |
| T942 | CRRENtMKNVG | PhosphoSitePlus | |
| S395 | EECCTsSGCQS | PhosphoSitePlus | |
| S916 | KYAFNsLQLKA | HPRD | |
| T22 | MQRAStIDVAA | PhosphoSitePlus | |
| T137 | LLGSGtFIVKD | PhosphoSitePlus; HPRD | |
| S252 | EQMAEsVLSLH | PhosphoSitePlus | |
| Y965 | AFPKHyRPPEG | PhosphoSitePlus | |
| Y481 | AARPDyIASKA | PhosphoSitePlus | |
| Y427 | KTQVSyYAERL | PhosphoSitePlus | |
| S21 | AMQRAsTIDVA | PhosphoSitePlus | |
| S433 | YAERLsRAAKD | PhosphoSitePlus | |
| S955 | KYAFNsLQLKA | PhosphoSitePlus | |
| T394 | FEECCtSSGCQ | PhosphoSitePlus | |
| S487 | IASKAsPTSTE | PhosphoSitePlus | |
| S490 | KASPTsTEEEQ | PhosphoSitePlus | |
| S851 | LPRSRsQTCLP | PhosphoSitePlus | |
| Y355 | GSDQNyDIVTI | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| INP4A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| INP4A_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000074304 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.26 | 15169874 |
| Hyperphosphorylation site |
| INP4A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| INP4A_HUMAN | INPP_HUMAN | enzyme catalysis | KEGG |
| IMPA1_HUMAN | INP4A_HUMAN | enzyme catalysis | KEGG |
| PTEN_HUMAN | INP4A_HUMAN | enzyme catalysis | KEGG |
| INP4A_HUMAN | MTM1_HUMAN | enzyme catalysis | KEGG |
| INP4A_HUMAN | FYV1_HUMAN | enzyme catalysis | KEGG |
| PI3R5_HUMAN | INP4A_HUMAN | enzyme catalysis | KEGG |
| INP4A_HUMAN | PI3R5_HUMAN | enzyme catalysis | KEGG |
| INP4A_HUMAN | SHIP1_HUMAN | enzyme catalysis | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00562 | Inositol phosphate metabolism |
| hsa01100 | Metabolic pathways |
| hsa04070 | Phosphatidylinositol signaling system |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatas | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatas | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |