Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MTM1_HUMAN
Description:myotubularin 1 [Source:HGNC Symbol;Acc:7448]
Location:chrX q28
Node attribute:Enzyme(source); Enzyme(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y260KDDEKyLDVIRMyotub-relatedPhosphoSitePlus
Y277SKLTIyDARPSMyotub-relatedPhosphoSitePlus
S297GGGYEsDDAYHMyotub-relatedPhosphoSitePlus
T601MPHVQtHPRD
T112YGLDItCKDMRPhosphoSitePlus
S13KYNSHsLENESPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S583NSAKLsDPPTSHPRD
Y107RGENSyGLDITPhosphoSitePlus
S18SLENEsIKRTSPhosphoSitePlus; HPRD
S106SRGENsYGLDIPhosphoSitePlus
S591PTSPSsPSQMMPhosphoSitePlus; HPRD
Y301ESDDAyHNAELMyotub-relatedPhosphoSitePlus
Y71TNYRLyLRSLEGRAMPhosphoSitePlus
S590PPTSPsSPSQMPhosphoSitePlus; HPRD
S588SDPPTsPSSPSPhosphoSitePlus; HPRD
Y557PVEQRyMELLAPhosphoSitePlus
S91PLGVIsRIEKMGRAMPhosphoSitePlus
Y295ATGGGyESDDAMyotub-relatedPhosphoSitePlus
T495KVTERtVSLWSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T587LSDPPtSPSSPHPRD

Dephosphorylation site
MTM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359423P226STCGAOvarian Cancer21720365, 18772890
ENSP00000359423P226SCOSMICOvarian Cancer21720365
ENSP00000359423R486*COSMICHead and Neck Cancer21798897
ENSP00000359423A99TBIOMARTBreast Cancer21930507, 21930502
ENSP00000359423I405VCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
MTM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MTM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDIPT_HUMANMTM1_HUMANenzyme catalysisKEGG
FYV1_HUMANMTM1_HUMANenzyme catalysisKEGG
SHIP1_HUMANMTM1_HUMANenzyme catalysisKEGG
PTEN_HUMANMTM1_HUMANenzyme catalysisKEGG
MTM1_HUMANIMPA1_HUMANenzyme catalysisKEGG
PI3R5_HUMANMTM1_HUMANenzyme catalysisKEGG
PI4KA_HUMANMTM1_HUMANenzyme catalysisKEGG
INP4A_HUMANMTM1_HUMANenzyme catalysisKEGG
PLCD3_HUMANMTM1_HUMANenzyme catalysisKEGG
PI51C_HUMANMTM1_HUMANenzyme catalysisKEGG
I5P2_HUMANMTM1_HUMANenzyme catalysisKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035091phosphatidylinositol bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0045109intermediate filament organizationIMPbiological_process
GO:0031674I bandIEAcellular_component
GO:0006644phospholipid metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0052629phosphatidylinositol-3,5-bisphosphate 3-phosphatasIDAmolecular_function
GO:0019215intermediate filament bindingIDAmolecular_function
GO:0001726ruffleIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0006470protein dephosphorylationIDAbiological_process
GO:0048311mitochondrion distributionIEAbiological_process
GO:0004721phosphoprotein phosphatase activityIDAmolecular_function
GO:0046716muscle cell homeostasisIEAbiological_process
GO:0044088regulation of vacuole organizationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0016311dephosphorylationIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0070584mitochondrion morphogenesisIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0016791phosphatase activityIEAmolecular_function
GO:0046856phosphatidylinositol dephosphorylationIDAbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0030175filopodiumIDAcellular_component
GO:0004438phosphatidylinositol-3-phosphatase activityIDAmolecular_function
GO:0008333endosome to lysosome transportIDAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0005770late endosomeIDAcellular_component


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