Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:I5P2_HUMAN
Description:inositol polyphosphate-5-phosphatase, 75kDa [Source:HGNC Symbol;Acc:6077]
Location:chr1 p34.3
Node attribute:Enzyme(target); Enzyme(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y933KNVFHyLMAFLRhoGAPPhosphoSitePlus
T586TYKYDtGSDDWExo_endo_phosPhosphoSitePlus
Y684FQNVKyMQLKVPhosphoSitePlus
Y352IMLLLyVKQEHHPRD

Dephosphorylation site
I5P2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362117H695NCOSMICPancreatic Cancer21252315
ENSP00000362117V406LCOSMICOvarian Cancer21720365

Differential expressed protein
I5P2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
I5P2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PI4KA_HUMANI5P2_HUMANenzyme catalysisKEGG
I5P2_HUMANPI42A_HUMANenzyme catalysisKEGG
PLCD3_HUMANI5P2_HUMANenzyme catalysisKEGG
I5P2_HUMANPLCD3_HUMANenzyme catalysisKEGG
PTEN_HUMANI5P2_HUMANenzyme catalysisKEGG
PI3R5_HUMANI5P2_HUMANenzyme catalysisKEGG
PI51C_HUMANI5P2_HUMANenzyme catalysisKEGG
I5P2_HUMANPTEN_HUMANenzyme catalysisKEGG
I5P2_HUMANMTM1_HUMANenzyme catalysisKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
hsa00562Inositol phosphate metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046854phosphatidylinositol phosphorylationIEAbiological_process
GO:0052658inositol-1,4,5-trisphosphate 5-phosphatase activitIDAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0030317sperm motilityIEAbiological_process
GO:0016020membraneIDAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0005793endoplasmic reticulum-Golgi intermediate compartmeIEAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005829cytosolIDAcellular_component
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030670phagocytic vesicle membraneIEAcellular_component
GO:0070613regulation of protein processingIEAbiological_process
GO:0031901early endosome membraneIEAcellular_component
GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatasIDAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0046856phosphatidylinositol dephosphorylationIDAbiological_process


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