UniProt/SwissProt ID: | I5P2_HUMAN |
Description: | inositol polyphosphate-5-phosphatase, 75kDa [Source:HGNC Symbol;Acc:6077] |
Location: | chr1 p34.3 |
Node attribute: | Enzyme(target); Enzyme(source) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
Y933 | KNVFHyLMAFL | RhoGAP | PhosphoSitePlus |
T586 | TYKYDtGSDDW | Exo_endo_phos | PhosphoSitePlus |
Y684 | FQNVKyMQLKV | PhosphoSitePlus | |
Y352 | IMLLLyVKQEH | HPRD | |
Dephosphorylation site |
I5P2_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000362117 | H695N | COSMIC | Pancreatic Cancer | 21252315 |
ENSP00000362117 | V406L | COSMIC | Ovarian Cancer | 21720365 |
Differential expressed protein |
I5P2_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
I5P2_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
PI4KA_HUMAN | I5P2_HUMAN | enzyme catalysis | KEGG |
I5P2_HUMAN | PI42A_HUMAN | enzyme catalysis | KEGG |
PLCD3_HUMAN | I5P2_HUMAN | enzyme catalysis | KEGG |
I5P2_HUMAN | PLCD3_HUMAN | enzyme catalysis | KEGG |
PTEN_HUMAN | I5P2_HUMAN | enzyme catalysis | KEGG |
PI3R5_HUMAN | I5P2_HUMAN | enzyme catalysis | KEGG |
PI51C_HUMAN | I5P2_HUMAN | enzyme catalysis | KEGG |
I5P2_HUMAN | PTEN_HUMAN | enzyme catalysis | KEGG |
I5P2_HUMAN | MTM1_HUMAN | enzyme catalysis | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa01100 | Metabolic pathways |
hsa04070 | Phosphatidylinositol signaling system |
hsa00562 | Inositol phosphate metabolism |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0046854 | phosphatidylinositol phosphorylation | IEA | biological_process |
GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activit | IDA | molecular_function |
GO:0007165 | signal transduction | IEA | biological_process |
GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
GO:0007283 | spermatogenesis | IEA | biological_process |
GO:0030317 | sperm motility | IEA | biological_process |
GO:0016020 | membrane | IDA | cellular_component |
GO:0005622 | intracellular | IEA | cellular_component |
GO:0005793 | endoplasmic reticulum-Golgi intermediate compartme | IEA | cellular_component |
GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
GO:0005829 | cytosol | IEA | cellular_component |
GO:0005829 | cytosol | IDA | cellular_component |
GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
GO:0016021 | integral to membrane | IEA | cellular_component |
GO:0005737 | cytoplasm | IDA | cellular_component |
GO:0001701 | in utero embryonic development | IEA | biological_process |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0030670 | phagocytic vesicle membrane | IEA | cellular_component |
GO:0070613 | regulation of protein processing | IEA | biological_process |
GO:0031901 | early endosome membrane | IEA | cellular_component |
GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatas | IDA | molecular_function |
GO:0046872 | metal ion binding | IEA | molecular_function |
GO:0005794 | Golgi apparatus | IEA | cellular_component |
GO:0046856 | phosphatidylinositol dephosphorylation | IDA | biological_process |