Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:4F2_HUMAN
Description:solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 [Source:HGNC Symbol;Acc:11026]
Location:chr11 q12.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2DTEVHPRD; phosphoELM; SysPTM
Y312DLTPNyRGENSHPRD
S200SAKKKsIRVILHPRD
T5VDMKHPRD; phosphoELM; SysPTM
S165KFTGLsKEELLPhosphoSitePlus
S545GREEGsPLELEHPRD
Y250DLTPNyRGENSHPRD
S506GREEGsPLELEHPRD
S527LFRRLsDQRSKDUF3459PhosphoSitePlus
S239SAKKKsIRVILHPRD
T162AAAKFtGLSKEPhosphoSitePlus
S607GREEGsPLELEHPRD
T321NSWFStQVDTVAlpha-amylasePhosphoSitePlus
S410LSDSGsTGEHTPhosphoSitePlus
S72SGAAMsLAGAEHPRD
Y211DLTPNyRGENSHPRD
S406TSSYLsDSGSTPhosphoSitePlus
S33SGAAMsLAGAEHPRD; SysPTM
S9QPPEAsIAVVSPhosphoSitePlus; HPRD
T106TMSQDtEVDMKPhosphoSitePlus; HPRD
S103VTGTMsQDTEVPhosphoSitePlus; HPRD
S607GREEGsPLELEDUF3459PhosphoSitePlus
S320ENSWFsTQVDTAlpha-amylasePhosphoSitePlus
S134SGAAMsLAGAEPhosphoSitePlus; HPRD
T44TMSQDtEVDMKHPRD
S531LSDQRsKERSLDUF3459PhosphoSitePlus
S408SYLSDsGSTGEPhosphoSitePlus
S301SAKKKsIRVILHPRD
S41DSGTMsQDTEVHPRD

Dephosphorylation site
4F2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367124S552FCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000367124Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.1718646787
ENSP00000367124Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3118646787
ENSP00000367124Breast CancerTreatment (mitoxantrone-sensitive vs. mitoxantrone-resistant)cell lineUp4.416335961
ENSP00000367124Breast CancerMetastasiscell lineDown0.4318729497
ENSP00000367124Breast CancerMetastasiscell lineDown0.4518729497
ENSP00000367124Breast CancerMetastasiscell lineDown0.519321434
ENSP00000367124Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueUp1.819329653
ENSP00000367124LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineDown17449014

Hyperphosphorylation site
4F2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JUN_HUMAN4F2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
4F2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006865amino acid transportTASbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0060356leucine importIEAbiological_process
GO:0016049cell growthNASbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0016021integral to membraneNAScellular_component
GO:0006811ion transportTASbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0006816calcium ion transportNASbiological_process
GO:0015175neutral amino acid transmembrane transporter activIEAmolecular_function
GO:0050900leukocyte migrationTASbiological_process
GO:0043169cation bindingIEAmolecular_function
GO:0005975carbohydrate metabolic processIEAbiological_process
GO:0005432calcium:sodium antiporter activityTASmolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0015827tryptophan transportISSbiological_process
GO:0009986cell surfaceIDAcellular_component


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