Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MSH2_HUMAN
Description:mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) [Source:HGNC Symbol;Acc:7325]
Location:chr2 p21
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y863GESQGyDIMEPPhosphoSitePlus
T897KQMPFtEMSEEPhosphoSitePlus; HPRD
T32PEKPTtTVRLFHPRD
S734MLETAsILRSAHPRD
T206LPGGEtAGDMGHPRD
T206LPGGEtAGDMGMutS_IIPhosphoSitePlus
T732AEMLEtASILRHPRD
Y66QGVIKyMGPAGMutS_IPhosphoSitePlus
S900PFTEMsEENITPhosphoSitePlus; HPRD
S77AKNLQsVVLSKMutS_IPhosphoSitePlus
S860QYIGEsQGYDIPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
MSH2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000233146S585fs*5COSMICIntestines Cancer15926618
ENSP00000233146H46QHPIColorectal Cancer9259192 8700523 18033691
ENSP00000233146R406*COSMICIntestines Cancer9087566
ENSP00000233146H639RHPIColorectal Cancer9259192 9419403 18822302
ENSP00000233146E467KCOSMICBreast Cancer
ENSP00000233146H839RHPIColorectal Cancer9259192 15613555
ENSP00000233146I679THPIColorectal Cancer9259192 9419403
ENSP00000233146N127SHPIColorectal Cancer9259192 12655564 18951462 20438357 18951462 18470917 16252083 12655564
ENSP00000233146G587RCOSMICIntestines Cancer12386821
ENSP00000233146D660GHPIColorectal Cancer9259192 14635101
ENSP00000233146T44MHPIColorectal Cancer9259192 12112654
ENSP00000233146K110THPIColorectal Cancer9259192 9419403
ENSP00000233146P336SHPIColorectal Cancer9259192 10375096
ENSP00000233146A305THPIColorectal Cancer9259192 9311737 18822302
ENSP00000233146H639YOMIMColorectal Cancer8261515
ENSP00000233146M688IHPIColorectal Cancer9259192 9559627 10777691 15365995 15527911
ENSP00000233146I216VHPIColorectal Cancer9259192 11726306
ENSP00000233146G164RHPIColorectal Cancer9259192 17101317 18951462 18951462
ENSP00000233146E562VHPIColorectal Cancer9259192 9048925
ENSP00000233146V17FHPIGastric Cancer9259192 12132870
ENSP00000233146E749*COSMICIntestines Cancer8872463
ENSP00000233146G827RCOSMICIntestines Cancer12386821
ENSP00000233146R359SHPIColorectal Cancer9259192 11870161 18781619 18781619
ENSP00000233146L175PHPIColorectal Cancer9259192 12655568
ENSP00000233146L173PHPIColorectal Cancer9259192 17101317 18951462 18951462
ENSP00000233146E853AHPIColorectal Cancer9259192 12362047 16451135
ENSP00000233146P622LOMIM, HPIColorectal Cancer12694232 8261515, 8261515 9259192 10469597 11555625 12124176 18822302 15354210
ENSP00000233146N671YHPIColorectal Cancer9259192 15300854 18561205
ENSP00000233146P868AHPIGastric Cancer9259192 12132870
ENSP00000233146V923EHPIColorectal Cancer9259192 12112654 17101317 18951462 21431882 18951462
ENSP00000233146Y98CHPIColorectal Cancer9259192 12132870
ENSP00000233146V161DHPIColorectal Cancer9259192 11726306 17101317 18951462 18951462
ENSP00000233146M492VHPIColorectal Cancer9259192
ENSP00000233146L390FHPIColorectal Cancer9259192 8690195 9621522 10469597 10386556 12792735 15996210 16451135 16929514 17011982 15527911 14499697
ENSP00000233146V163DHPIColorectal Cancer9259192 12200596
ENSP00000233146K393MHPIColorectal Cancer9259192 12124176
ENSP00000233146G692ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000233146C822*COSMICIntestines Cancer8589682
ENSP00000233146A714VHPIColorectal Cancer9259192 12132870
ENSP00000233146A2THPIColorectal Cancer9259192 16451135
ENSP00000233146S723FHPIColorectal Cancer9259192 11920458 18561205
ENSP00000233146C822FCOSMICMelanoma
ENSP00000233146K845EHPIColorectal Cancer9259192 10777691
ENSP00000233146R711*COSMICLymphoma
ENSP00000233146T552PHPIColorectal Cancer9259192 12658575
ENSP00000233146C333YHPIColorectal Cancer9259192 17101317 18951462 18951462
ENSP00000233146L93FHPIColorectal Cancer9259192 15896463
ENSP00000233146P349LHPIColorectal Cancer9259192 15342696 21926548
ENSP00000233146S554RHPIColorectal Cancer9259192 11726306
ENSP00000233146L312fs*19COSMICIntestines Cancer8613431
ENSP00000233146W345*COSMICBreast Cancer22034109
ENSP00000233146G674SCOSMICIntestines Cancer8589682
ENSP00000233146L187PHPIColorectal Cancer9259192 17101317 18951462 18951462
ENSP00000233146A230fs*16COSMICIntestines Cancer15063132
ENSP00000233146E886GHPIColorectal Cancer9259192 12112654
ENSP00000233146C873GHPIGastric Cancer9259192 12132870
ENSP00000233146N583SHPIColorectal Cancer9259192 12658575
ENSP00000233146E647KHPIColorectal Cancer9259192 9419403
ENSP00000233146D167HHPIColorectal Cancer9259192 8872463 12124176 11870161 18781619 18781619 18822302
ENSP00000233146A870GHPIGastric Cancer9259192 12132870
ENSP00000233146G220*COSMICIntestines Cancer8589682
ENSP00000233146P69TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000233146G674SHPIColorectal Cancer9259192 12124176
ENSP00000233146L478FCOSMICSkin Cancer21984974
ENSP00000233146T732IHPIColorectal Cancer9259192 9419403
ENSP00000233146C199RHPINeoplasms by Histologic Type9259192 9777949 18561205
ENSP00000233146Y656HHPIColorectal Cancer9259192 9419403
ENSP00000233146C697RHPIColorectal Cancer9259192 10612836 18561205 21239990
ENSP00000233146D603NCOSMICBreast Cancer22034109
ENSP00000233146Q824EBIOMARTBreast Cancer21930507, 21930502
ENSP00000233146V102IHPIColorectal Cancer9259192 12200596
ENSP00000233146G162AHPIColorectal Cancer9259192 17128465
ENSP00000233146R524fs*2COSMICUterine Cancer17250671
ENSP00000233146M813VHPIColorectal Cancer9259192 12373605
ENSP00000233146R524POMIM, HPIColorectal Cancer7937795, 9889267 9259192 10469597 12124176 7937795
ENSP00000233146S860*COSMICUterine Cancer
ENSP00000233146I169VHPIColorectal Cancer9259192 12792735 15996210
ENSP00000233146T33PHPIColorectal Cancer9259192 17101317 18951462 18951462
ENSP00000233146T335IHPIColorectal Cancer9259192 12132870
ENSP00000233146Q629RHPIColorectal Cancer9259192 12132870 12792735 15365995 15613555 15996210
ENSP00000233146T564AHPIColorectal Cancer9259192 12200596 15996210
ENSP00000233146E768fs*44COSMICUterine Cancer
ENSP00000233146S323YHPIColorectal Cancer9259192 12132870
ENSP00000233146Q413*COSMICIntestines Cancer8952554
ENSP00000233146E198GHPIColorectal Cancer9259192
ENSP00000233146L496*COSMICIntestines Cancer8589682
ENSP00000233146E647*COSMICIntestines Cancer15926618
ENSP00000233146G751fs*12COSMICOvarian Cancer21720365
ENSP00000233146V342IHPIColorectal Cancer9259192 14504054
ENSP00000233146E749KHPIColorectal Cancer9259192 17101317 18951462 18951462
ENSP00000233146S13IHPIColorectal Cancer9259192 14504054
ENSP00000233146N139SHPIColorectal Cancer9259192
ENSP00000233146G322DCOSMICIntestines Cancer14688830
ENSP00000233146I237VCOSMICIntestines Cancer16902769
ENSP00000233146R680*COSMICIntestines Cancer
ENSP00000233146K246QHPIColorectal Cancer9259192 10573010
ENSP00000233146D603NHPIColorectal Cancer9259192 10829038 17101317 18951462 18951462
ENSP00000233146A834THPIColorectal Cancer9259192 9311737 10573010 17101317 18951462 18951462 18822302
ENSP00000233146A636POMIM, HPIColorectal Cancer12454801, 9259192 10528862 12658575 17101317 18951462 22219001 21419771 20850175 19101824 18951462 18674656 17414604 15516845 12595050
ENSP00000233146G692RHPIColorectal Cancer9259192 10612836
ENSP00000233146A600VHPIColorectal Cancer9259192 11920458 22086974
ENSP00000233146M729VHPIColorectal Cancer9259192 9419403
ENSP00000233146T905RHPIColorectal Cancer9259192 12124176 8880570
ENSP00000233146A45VHPIColorectal Cancer9259192 12112654
ENSP00000233146I145MHPIColorectal Cancer9259192 16451135
ENSP00000233146N596SHPIColorectal Cancer9259192 8993976 10573010 18033691
ENSP00000233146K931THPIColorectal Cancer9259192 15046096
ENSP00000233146D283YHPIColorectal Cancer9259192 15870828
ENSP00000233146F694fs*16COSMICIntestines Cancer9087566
ENSP00000233146Q824EHPIGastric Cancer9259192 12132870
ENSP00000233146G692ECOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000233146Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
MSH2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JUN_HUMANMSH2_HUMANTF -> target geneTRANSFAC
P53_HUMANMSH2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MSH2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007050cell cycle arrestIEAbiological_process
GO:0045190isotype switchingIEAbiological_process
GO:0032405MutLalpha complex bindingIDAmolecular_function
GO:0032143single thymine insertion bindingIDAmolecular_function
GO:0008584male gonad developmentIEAbiological_process
GO:0000228nuclear chromosomeIBAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0000406double-strand/single-strand DNA junction bindingIBAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0032181dinucleotide repeat insertion bindingIDAmolecular_function
GO:0006298mismatch repairIEAbiological_process
GO:0032357oxidized purine DNA bindingIDAmolecular_function
GO:0000400four-way junction DNA bindingIDAmolecular_function
GO:0019724B cell mediated immunityISSbiological_process
GO:0030983mismatched DNA bindingIDAmolecular_function
GO:0006311meiotic gene conversionIBAbiological_process
GO:0032301MutSalpha complexIEAcellular_component
GO:0016447somatic recombination of immunoglobulin gene segmeISSbiological_process
GO:0008340determination of adult lifespanIEAbiological_process
GO:0000403Y-form DNA bindingIBAmolecular_function
GO:0042771intrinsic apoptotic signaling pathway in response IBAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0051096positive regulation of helicase activityIDAbiological_process
GO:0008094DNA-dependent ATPase activityIBAmolecular_function
GO:0016887ATPase activityIEAmolecular_function
GO:0003690double-stranded DNA bindingIDAmolecular_function
GO:0006119oxidative phosphorylationIEAbiological_process
GO:0010165response to X-rayIEAbiological_process
GO:0043570maintenance of DNA repeat elementsIMPbiological_process
GO:0006281DNA repairIDAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0032137guanine/thymine mispair bindingIEAmolecular_function
GO:0010224response to UV-BIEAbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0006200ATP catabolic processIDAbiological_process
GO:0000710meiotic mismatch repairIBAbiological_process
GO:0032302MutSbeta complexIEAcellular_component
GO:0031573intra-S DNA damage checkpointIEAbiological_process
GO:0002204somatic recombination of immunoglobulin genes invoIEAbiological_process
GO:0032139dinucleotide insertion or deletion bindingIDAmolecular_function
GO:0007281germ cell developmentIEAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0043531ADP bindingIDAmolecular_function
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0000404loop DNA bindingIBAmolecular_function
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0003697single-stranded DNA bindingIDAmolecular_function
GO:0045128negative regulation of reciprocal meiotic recombinIBAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0045910negative regulation of DNA recombinationIEAbiological_process
GO:0006301postreplication repairIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0019237centromeric DNA bindingIEAmolecular_function
GO:0016447somatic recombination of immunoglobulin gene segmeIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0019724B cell mediated immunityIEAbiological_process
GO:0032142single guanine insertion bindingIDAmolecular_function
GO:0030183B cell differentiationIEAbiological_process
GO:0016446somatic hypermutation of immunoglobulin genesIEAbiological_process
GO:0030983mismatched DNA bindingIEAmolecular_function