Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IFNB_HUMAN
Description:interferon, beta 1, fibroblast [Source:HGNC Symbol;Acc:5434]
Location:chr9 p21.3
Node attribute:PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S140GKLMSsLHLKRInterferonPhosphoSitePlus

Dephosphorylation site
IFNB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369581W164CSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000369581N111KCOSMICOvarian Cancer21720365

Differential expressed protein
IFNB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IFNB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IFNB_HUMANINAR1_HUMANotherKEGG
IRF7_HUMANIFNB_HUMANTF -> target geneKEGG
IRF3_HUMANIFNB_HUMANTF -> target geneKEGG
SUH_HUMANIFNB_HUMANTF -> target geneTRANSFAC
IRF3_HUMANIFNB_HUMANTF -> target geneTRANSFAC
TF65_HUMANIFNB_HUMANTF -> target geneTRANSFAC
JUN_HUMANIFNB_HUMANTF -> target geneTRANSFAC
REL_HUMANIFNB_HUMANTF -> target geneTRANSFAC
IRF7_HUMANIFNB_HUMANTF -> target geneTRANSFAC
PRDM1_HUMANIFNB_HUMANTF -> target geneTRANSFAC
ATF2_HUMANIFNB_HUMANTF -> target geneTRANSFAC
ZEP1_HUMANIFNB_HUMANTF -> target geneTRANSFAC
IRF2_HUMANIFNB_HUMANTF -> target geneTRANSFAC
IBP1_HUMANIFNB_HUMANTF -> target geneTRANSFAC
IRF1_HUMANIFNB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa05164Influenza A
hsa04622RIG-I-like receptor signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa05142Chagas disease (American trypanosomiasis)
hsa04650Natural killer cell mediated cytotoxicity
hsa05160Hepatitis C
hsa04380Osteoclast differentiation
hsa05152Tuberculosis
hsa05162Measles
hsa04620Toll-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0045089positive regulation of innate immune responseNASbiological_process
GO:0005576extracellular regionICcellular_component
GO:0033141positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0042742defense response to bacteriumIEAbiological_process
GO:0046597negative regulation of viral entry into host cellNASbiological_process
GO:0002250adaptive immune responseIEAbiological_process
GO:0051607defense response to virusIDAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityNASbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0006917induction of apoptosisIDAbiological_process
GO:0045581negative regulation of T cell differentiationIDAbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0009615response to virusNASbiological_process
GO:0045343regulation of MHC class I biosynthetic processNASbiological_process
GO:0032897negative regulation of viral transcriptionIDAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0071360cellular response to exogenous dsRNAIMPbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0030101natural killer cell activationNASbiological_process
GO:0005132interferon-alpha/beta receptor bindingNASmolecular_function
GO:0042100B cell proliferationNASbiological_process
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0006959humoral immune responseIEAbiological_process
GO:0006952defense responseIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0008285negative regulation of cell proliferationNASbiological_process
GO:2000552negative regulation of T-helper 2 cell cytokine prIDAbiological_process
GO:0005126cytokine receptor bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0045071negative regulation of viral genome replicationIDAbiological_process


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