Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	IFNB_HUMAN
Description:	interferon, beta 1, fibroblast [Source:HGNC Symbol;Acc:5434]
Location:	chr9 p21.3
Node attribute:	PPI(source); gene

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S140	GKLMSsLHLKR	Interferon	PhosphoSitePlus

Dephosphorylation site

IFNB_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000369581	W164C	Sjoblom2006, COSMIC, HPI	Breast Cancer	16959974
ENSP00000369581	N111K	COSMIC	Ovarian Cancer	21720365

Differential expressed protein

IFNB_HUMAN is not differential expressed protein.

Hyperphosphorylation site

IFNB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
IFNB_HUMAN	INAR1_HUMAN	other	KEGG
IRF7_HUMAN	IFNB_HUMAN	TF -> target gene	KEGG
IRF3_HUMAN	IFNB_HUMAN	TF -> target gene	KEGG
SUH_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
IRF3_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
TF65_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
REL_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
IRF7_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
PRDM1_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
ATF2_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
ZEP1_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
IRF2_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
IBP1_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05168	Herpes simplex infection
hsa05164	Influenza A
hsa04622	RIG-I-like receptor signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa05142	Chagas disease (American trypanosomiasis)
hsa04650	Natural killer cell mediated cytotoxicity
hsa05160	Hepatitis C
hsa04380	Osteoclast differentiation
hsa05152	Tuberculosis
hsa05162	Measles
hsa04620	Toll-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa04630	Jak-STAT signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0019221	cytokine-mediated signaling pathway	TAS	biological_process
GO:0060338	regulation of type I interferon-mediated signaling	TAS	biological_process
GO:0045089	positive regulation of innate immune response	NAS	biological_process
GO:0005576	extracellular region	IC	cellular_component
GO:0033141	positive regulation of peptidyl-serine phosphoryla	IDA	biological_process
GO:0042742	defense response to bacterium	IEA	biological_process
GO:0046597	negative regulation of viral entry into host cell	NAS	biological_process
GO:0002250	adaptive immune response	IEA	biological_process
GO:0051607	defense response to virus	IDA	biological_process
GO:0006919	activation of cysteine-type endopeptidase activity	NAS	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0006917	induction of apoptosis	IDA	biological_process
GO:0045581	negative regulation of T cell differentiation	IDA	biological_process
GO:0060337	type I interferon-mediated signaling pathway	TAS	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IDA	biological_process
GO:0009615	response to virus	NAS	biological_process
GO:0045343	regulation of MHC class I biosynthetic process	NAS	biological_process
GO:0032897	negative regulation of viral transcription	IDA	biological_process
GO:0051607	defense response to virus	IEA	biological_process
GO:0071360	cellular response to exogenous dsRNA	IMP	biological_process
GO:0045087	innate immune response	TAS	biological_process
GO:0030101	natural killer cell activation	NAS	biological_process
GO:0005132	interferon-alpha/beta receptor binding	NAS	molecular_function
GO:0042100	B cell proliferation	NAS	biological_process
GO:0003714	transcription corepressor activity	IDA	molecular_function
GO:0006959	humoral immune response	IEA	biological_process
GO:0006952	defense response	IEA	biological_process
GO:0007166	cell surface receptor signaling pathway	TAS	biological_process
GO:0008285	negative regulation of cell proliferation	NAS	biological_process
GO:2000552	negative regulation of T-helper 2 cell cytokine pr	IDA	biological_process
GO:0005126	cytokine receptor binding	IEA	molecular_function
GO:0007596	blood coagulation	TAS	biological_process
GO:0005615	extracellular space	IEA	cellular_component
GO:0045071	negative regulation of viral genome replication	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network