Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANF_HUMAN
Description:natriuretic peptide A [Source:HGNC Symbol;Acc:7939]
Location:chr1 p36.22
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y151CNSFRyRR___PhosphoSitePlus

Dephosphorylation site
ANF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365663Y151HCOSMICOvarian Cancer21720365
ENSP00000365663P89ACOSMICHead and Neck Cancer21798893

Differential expressed protein
ANF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ANF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANF_HUMANANPRC_HUMANligand -> receptorHPMR
ANF_HUMANANPRA_HUMANligand -> receptorHPMR
JUN_HUMANANF_HUMANTF -> target geneTRANSFAC
NKX25_HUMANANF_HUMANTF -> target geneTRANSFAC
TBX5_HUMANANF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ANF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005576extracellular regionNAScellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0006182cGMP biosynthetic processIEAbiological_process
GO:0005179hormone activityIEAmolecular_function
GO:0042629mast cell granuleIEAcellular_component
GO:0007168receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0032868response to insulin stimulusIEAbiological_process
GO:0051428peptide hormone receptor bindingIEAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0050880regulation of blood vessel sizeIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0008217regulation of blood pressureIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0014898cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0007565female pregnancyIEAbiological_process


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