Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCB_HUMAN
Description:protein kinase C, beta [Source:HGNC Symbol;Acc:9395]
Location:chr16 p12.2
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S11AGPPPsEGEESHPRD
T497IWDGVtTKTFCPkinasePhosphoSitePlus
T17EGEEStVRFARPKCbRegPhos
S311ERAKIsQGTKVPhosphoSitePlus
T635FDKEFtRQPVEPKCbRegPhos
T314KISQGtKVPEEautocatalysis RegPhos
T500GVTTKtFCGTPPkinasePhosphoSitePlus
Y195GLSDPyVKLKLC2PhosphoSitePlus
T500GVTTKtFCGTPHPRD; phosphoELM; RegPhos
S661EFAGFsYTNPEautocatalysis RegPhos
Y368GTDELyAVKILPkinasePhosphoSitePlus
T48FFKQPtFCSHCC1_1PhosphoSitePlus
T17EGEEStVRFARPRKCBHPRD
T635FDKEFtRQPVEPRKCBHPRD
Y422YFVMEyVNGGDPkinasePhosphoSitePlus
S16SEGEEsTVRFAPKCbRegPhos
T498WDGVTtKTFCGPkinasePhosphoSitePlus
T504KTFCGtPDYIAPkinasePhosphoSitePlus; SysPTM
T642QPVELtPTDKLHPRD; phosphoELM; RegPhos; SysPTM
Y515PEIIAyQPYGKPkinasePhosphoSitePlus
T226PEWNEtFRFQLC2PhosphoSitePlus
Y123CGSLLyGLIHQC1_1PhosphoSitePlus
T17EGEEStVRFARautocatalysis RegPhos
T641HPPVLtPPDQEHPRD
Y507CGTPDyIAPEIPkinasePhosphoSitePlus
T642QPVELtPTDKLPkinase_CPhosphoSitePlus; SysPTM
Y417TMDRLyFVMEYPkinasePhosphoSitePlus
S16SEGEEsTVRFAPRKCBHPRD
T134GMKCDtCMMNVC1_1PhosphoSitePlus
S16SEGEEsTVRFAautocatalysis RegPhos
S660EFEGFsFVNSEHPRD
T364SERKGtDELYAPkinasePhosphoSitePlus
T504KTFCGtPDYIAphosphoELM; RegPhos; SysPTM
T635FDKEFtRQPVEautocatalysisRegPhos
Y195GLSDPyVKLKLRegPhos
S654RNIDQsEFEGFHPRD
S476NVMLDsEGHIKPkinasePhosphoSitePlus
T324EKTTNtVSKFDautocatalysis RegPhos
S661EFAGFsYTNPEPkinase_CPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S661QNEFAGFsYTNPEFVPPP2CBHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318315V144MGreenman2007Intestines Cancer17344846
ENSP00000305355V496MGreenman2007Neoplasms by Histologic Type17344846
ENSP00000305355T108MCOSMICHead and Neck Cancer21798893
ENSP00000318315D237HBIOMARTBreast Cancer21930507, 21930502
ENSP00000318315F353LBIOMARTBreast Cancer21930507, 21930502
ENSP00000305355C386STCGAOvarian Cancer21720365, 18772890
ENSP00000305355Y109HCOSMICHead and Neck Cancer21798893
ENSP00000318315G88DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000318315V144MHPIColorectal Cancer17344846
ENSP00000305355V144MGreenman2007Intestines Cancer17344846
ENSP00000305355G262VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000305355F353LBIOMARTBreast Cancer21930507, 21930502
ENSP00000318315V496MGreenman2007, HPINeoplasms by Histologic Type17344846
ENSP00000305355G585SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000305355E606KCOSMICHepatocellular Carcinoma21822264
ENSP00000305355D237HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
KPCB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPCB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AVR2B_HUMANKPCB_HUMANkinase -> substrateRobert H Newman (2013)
PXK_HUMANKPCB_HUMANkinase -> substrateRobert H Newman (2013)
KPCB_HUMANANXA2_HUMANkinase -> substrateHPRD
KPCB_HUMANCD5_HUMANkinase -> substrateHPRD
KPCB_HUMANIF4E_HUMANkinase -> substrateHPRD
KPCB_HUMANNEUM_HUMANkinase -> substrateHPRD
KPCB_HUMANLMNB1_HUMANkinase -> substrateHPRD
KPCB_HUMANNMDE2_HUMANkinase -> substrateHPRD
KPCB_HUMANBTK_HUMANkinase -> substrateHPRD; NetPath
KPCB_HUMANDVL2_HUMANkinase -> substrateNetPath
KPCB_HUMAN41_HUMANkinase -> substrateHPRD
KPCB_HUMANCAR11_HUMANkinase -> substrateKEGG; NetPath
KPCB_HUMANPTN11_HUMANkinase -> substrateHPRD
KPCB_HUMANMARCS_HUMANkinase -> substrateHPRD
KPCB_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCB_HUMANGRP3_HUMANkinase -> substrateNetPath
KPCB_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
KPCB_HUMANTOP2A_HUMANkinase -> substrateHPRD
KPCB_HUMANCASR_HUMANkinase -> substrateHPRD
KPCB_HUMANCXA1_HUMANkinase -> substrateHPRD
KPCB_HUMANNEUG_HUMANkinase -> substrateHPRD
BMX_HUMANKPCB_HUMANkinase -> substrateRobert H Newman (2013)
KPCB_HUMANKIT_HUMANkinase -> substrateNetPath
KPCB_HUMANPEBP1_HUMANkinase -> substrateHPRD
KPCB_HUMANDAB2_HUMANkinase -> substrateHPRD
KPCB_HUMANSTXB1_HUMANkinase -> substrateHPRD
KPCB_HUMANITB2_HUMANkinase -> substrateHPRD
KPCB_HUMANITB7_HUMANkinase -> substrateHPRD
KPCB_HUMANOCLN_HUMANkinase -> substrateHPRD
KPCB_HUMANIKKB_HUMANkinase -> substrateNetPath
KPCB_HUMANCYH2_HUMANkinase -> substrateHPRD
KPCB_HUMANKPCB_HUMANkinase -> substrateHPRD
KPCB_HUMANHABP4_HUMANkinase -> substrateHPRD
KPCB_HUMANVTNC_HUMANkinase -> substrateHPRD
KPCB_HUMANJADE1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKPCB_HUMANkinase -> substrateRegPhos
KPCB_HUMANSDC2_HUMANkinase -> substrateHPRD
KPCB_HUMANIF6_HUMANkinase -> substrateHPRD
KPCB_HUMANGSK3A_HUMANkinase -> substrateHPRD
KPCB_HUMANIKKA_HUMANkinase -> substrateNetPath
KPCB_HUMANRAD_HUMANkinase -> substrateHPRD
KPCB_HUMANPA2G4_HUMANkinase -> substrateHPRD
KPCB_HUMANCLAT_HUMANkinase -> substrateHPRD
PP2AB_HUMANKPCB_HUMANphosphatase -> substrateHPRD
PLCG2_HUMANKPCB_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04664Fc epsilon RI signaling pathway
hsa04912GnRH signaling pathway
hsa04971Gastric acid secretion
hsa04960Aldosterone-regulated sodium reabsorption
hsa04064NF-kappa B signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04062Chemokine signaling pathway
hsa04916Melanogenesis
hsa05032Morphine addiction
hsa04650Natural killer cell mediated cytotoxicity
hsa04530Tight junction
hsa05143African trypanosomiasis
hsa04010MAPK signaling pathway
hsa04726Serotonergic synapse
hsa04540Gap junction
hsa04725Cholinergic synapse
hsa05031Amphetamine addiction
hsa04662B cell receptor signaling pathway
hsa05140Leishmaniasis
hsa04150mTOR signaling pathway
hsa04370VEGF signaling pathway
hsa05214Glioma
hsa04666Fc gamma R-mediated phagocytosis
hsa05110Vibrio cholerae infection
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04730Long-term depression
hsa04720Long-term potentiation
hsa04970Salivary secretion
hsa04310Wnt signaling pathway
hsa04728Dopaminergic synapse
hsa04670Leukocyte transendothelial migration
hsa04012ErbB signaling pathway
hsa04972Pancreatic secretion
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04270Vascular smooth muscle contraction
hsa04724Glutamatergic synapse
hsa04727GABAergic synapse
hsa04973Carbohydrate digestion and absorption
hsa05223Non-small cell lung cancer
hsa04510Focal adhesion
hsa05164Influenza A
hsa05200Pathways in cancer
hsa05146Amoebiasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042953lipoprotein transportTASbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0042113B cell activationISSbiological_process
GO:0030374ligand-dependent nuclear receptor transcription coIMPmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0010829negative regulation of glucose transportIEAbiological_process
GO:0050861positive regulation of B cell receptor signaling pISSbiological_process
GO:0035403histone kinase activity (H3-T6 specific)IDAmolecular_function
GO:0006816calcium ion transportIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIMPbiological_process
GO:0051092positive regulation of NF-kappaB transcription facISSbiological_process
GO:0071322cellular response to carbohydrate stimulusIEAbiological_process
GO:0005080protein kinase C bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0050861positive regulation of B cell receptor signaling pIEAbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cISSbiological_process
GO:0030949positive regulation of vascular endothelial growthISSbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0003682chromatin bindingIDAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0050681androgen receptor bindingIDAmolecular_function
GO:0042393histone bindingIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030949positive regulation of vascular endothelial growthIEAbiological_process
GO:0046627negative regulation of insulin receptor signaling ISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004697protein kinase C activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0042113B cell activationIEAbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0035408histone H3-T6 phosphorylationIDAbiological_process
GO:0010829negative regulation of glucose transportISSbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0007165signal transductionNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045766positive regulation of angiogenesisISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005246calcium channel regulator activityIEAmolecular_function
GO:0050853B cell receptor signaling pathwayISSbiological_process
GO:0006468protein phosphorylationTASbiological_process