Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF6_HUMAN
Description:eukaryotic translation initiation factor 6 [Source:HGNC Symbol;Acc:6159]
Location:chr20 q11.22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S175QDELSsLLQVPeIF-6PhosphoSitePlus
S174DQDELsSLLQVeIF-6PhosphoSitePlus
S239TSMRDsLIDSLPhosphoSitePlus; SysPTM
Y113TTCNDyVALVHeIF-6PhosphoSitePlus
S235STIATsMRDSLPKCa(PKC alphaRegPhos
Y113TTCNDyVALVHHPRD; RegPhos
T245LIDSLt_____PhosphoSitePlus
S175QDELSsLLQVPCK1_groupRegPhos
S235STIATsMRDSLPKC_alphaphosphoELM
S230NEAQPsTIATSHPRD; phosphoELM
S175QDELSsLLQVPHPRD
S239TSMRDsLIDSHPRD; phosphoELM; SysPTM
S243DSLIDsLT___PhosphoSitePlus; SysPTM
T245LIDSHPRD
T234PSTIAtSMRDSPKCbRegPhos
T234PSTIAtSMRDSPRKCBHPRD
S235STIATsMRDSLPhosphoSitePlus; HPRD; phosphoELM
S174DQDELsSLLQVCK1_groupRegPhos
S243DSLIDsHPRD; phosphoELM; SysPTM

Dephosphorylation site
IF6_HUMAN do not have dephosphorylation site.

Mutation site
IF6_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000363574Hepatocellular CarcinomaNormal vs. Cancercell lineUp318646787
ENSP00000363574Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.818646787
ENSP00000363574Breast CancerNormal vs. Cancercell lineUp3.417022634
ENSP00000363574Breast CancerMetastasiscell lineDown0.3718582095

Hyperphosphorylation site
IF6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANIF6_HUMANkinase -> substrateRegPhos
KPCA_HUMANIF6_HUMANkinase -> substrateRobert H Newman (2013)
KPCB_HUMANIF6_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03008Ribosome biogenesis in eukaryotes

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0042256mature ribosome assemblyIEAbiological_process
GO:0043022ribosome bindingIEAmolecular_function
GO:0005882intermediate filamentIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005638lamin filamentIEAcellular_component
GO:0003743translation initiation factor activityIEAmolecular_function


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