| UniProt/SwissProt ID: | IF6_HUMAN |
| Description: | eukaryotic translation initiation factor 6 [Source:HGNC Symbol;Acc:6159] |
| Location: | chr20 q11.22 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S175 | QDELSsLLQVP | eIF-6 | PhosphoSitePlus |
| S174 | DQDELsSLLQV | eIF-6 | PhosphoSitePlus |
| S239 | TSMRDsLIDSL | PhosphoSitePlus; SysPTM | |
| Y113 | TTCNDyVALVH | eIF-6 | PhosphoSitePlus |
| S235 | STIATsMRDSL | PKCa(PKC alpha | RegPhos |
| Y113 | TTCNDyVALVH | HPRD; RegPhos | |
| T245 | LIDSLt_____ | PhosphoSitePlus | |
| S175 | QDELSsLLQVP | CK1_group | RegPhos |
| S235 | STIATsMRDSL | PKC_alpha | phosphoELM |
| S230 | NEAQPsTIATS | HPRD; phosphoELM | |
| S175 | QDELSsLLQVP | HPRD | |
| S239 | TSMRDsLIDS | HPRD; phosphoELM; SysPTM | |
| S243 | DSLIDsLT___ | PhosphoSitePlus; SysPTM | |
| T245 | LIDS | HPRD | |
| T234 | PSTIAtSMRDS | PKCb | RegPhos |
| T234 | PSTIAtSMRDS | PRKCB | HPRD |
| S235 | STIATsMRDSL | PhosphoSitePlus; HPRD; phosphoELM | |
| S174 | DQDELsSLLQV | CK1_group | RegPhos |
| S243 | DSLIDs | HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| IF6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| IF6_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000363574 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 3 | 18646787 | ENSP00000363574 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.8 | 18646787 | ENSP00000363574 | Breast Cancer | Normal vs. Cancer | cell line | Up | 3.4 | 17022634 | ENSP00000363574 | Breast Cancer | Metastasis | cell line | Down | 0.37 | 18582095 |
| Hyperphosphorylation site |
| IF6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | IF6_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | IF6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCB_HUMAN | IF6_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03008 | Ribosome biogenesis in eukaryotes |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0042256 | mature ribosome assembly | IEA | biological_process |
| GO:0043022 | ribosome binding | IEA | molecular_function |
| GO:0005882 | intermediate filament | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005638 | lamin filament | IEA | cellular_component |
| GO:0003743 | translation initiation factor activity | IEA | molecular_function |