Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PA2G4_HUMAN
Description:proliferation-associated 2G4, 38kDa [Source:HGNC Symbol;Acc:8550]
Location:chr12 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2EDEQHPRD; phosphoELM; SysPTM
T366SASRKtQKKKKPRKCBHPRD
S361ALLQSsASRKTTraCPhosphoSitePlus; SysPTM
T11EQQEQtIAEDLPhosphoSitePlus; HPRD
T366SASRKtQKKKKTraCPhosphoSitePlus
S360KALLQsSASRKHPRD
S44SSSGVsVLSLCPeptidase_M24PhosphoSitePlus
T261GLKMKtSRAFFPeptidase_M24PhosphoSitePlus
Y98KSDQDyILKEGPeptidase_M24PhosphoSitePlus
T386ATSGEtLEENEHPRD; phosphoELM; RegPhos; SysPTM
S361ALLQSsASRKTHPRD; phosphoELM; SysPTM
Y255DPSKQyGLKMKPeptidase_M24PhosphoSitePlus
S90CVCHFsPLKSDPeptidase_M24PhosphoSitePlus
T60MIMEEtGKIFKPeptidase_M24PhosphoSitePlus
T366SASRKtQKKKKPKCbRegPhos
T366SASRKtQKKKKPKCaRegPhos
T366SASRKtQKKKKPKCgRegPhos
S363LQSSAsRKTQKPKCgRegPhos
S363LQSSAsRKTQKPKCaRegPhos
S363LQSSAsRKTQKPKCbRegPhos
S363LQSSAsRKTQKTraCPhosphoSitePlus
S383AENATsGETLEHPRD
S360KALLQsSASRKTraCPhosphoSitePlus
T386ATSGEtLEENETraCPhosphoSitePlus; SysPTM
T19EDLVVtKYKMGHPRD; SysPTM
S335PMRITsGPFEPHPRD
S2MSGEDeQRegPhos; SysPTM
T366SASRKtQKKKKPRKCAHPRD
T366SASRKtQKKKKPRKCGHPRD
S363LQSSAsRKTQKPRKCGHPRD
S363LQSSAsRKTQKPRKCAHPRD
S363LQSSAsRKTQKPRKCBHPRD
S2____MsGEDEQPhosphoSitePlus; SysPTM
T366SASRKtQKKKKRegPhos

Dephosphorylation site
PA2G4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302886D394YBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000302886Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.520804217
ENSP00000302886Breast CancerNormal vs. CancertissueUp2.420005186
ENSP00000302886Ovarian CancerMetastasiscell lineUp17892554
ENSP00000302886Biliary Tract CancerMetastasiscell lineDown0.3319299076

Hyperphosphorylation site
PA2G4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCG_HUMANPA2G4_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPA2G4_HUMANkinase -> substrateRegPhos
KPCA_HUMANPA2G4_HUMANkinase -> substrateHPRD
KPCB_HUMANPA2G4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
PA2G4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008283cell proliferationTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0009987cellular processIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006364rRNA processingIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0006417regulation of translationIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0007050cell cycle arrestTASbiological_process
GO:0030529ribonucleoprotein complexIEAcellular_component