| UniProt/SwissProt ID: | CYH2_HUMAN |
| Description: | cytohesin 2 [Source:HGNC Symbol;Acc:9502] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S392 | RKKRIsVKKKQ | PKC_alpha | phosphoELM |
| T58 | NEGSKtLQRNR | Sec7 | PhosphoSitePlus |
| Y381 | SVDPFyEMLAA | PhosphoSitePlus | |
| T360 | RISAPtQEEKD | PH | PhosphoSitePlus |
| S392 | RKKRIsVKKKQ | PKC_group | phosphoELM; RegPhos |
| Y235 | LLRNLyDSIRN | Sec7 | PhosphoSitePlus |
| S392 | RKKRIsVKKKQ | PKCb | RegPhos |
| S392 | RKKRIsVKKKQ | PKCa(PKC alpha | RegPhos |
| S392 | RKKRIsVKKKQ | PhosphoSitePlus | |
| S392 | RKKRIsVKKKQ | PKCa | RegPhos |
| S392 | RKKRIsVKKKQ | PKCg | RegPhos |
| S56 | EANEGsKTLQR | PhosphoSitePlus | |
| Dephosphorylation site |
| CYH2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000408236 | G105W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000408236 | V192I | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| CYH2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CYH2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | CYH2_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCG_HUMAN | CYH2_HUMAN | kinase -> substrate | HPRD |
| KPCB_HUMAN | CYH2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| CYH2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030036 | actin cytoskeleton organization | TAS | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0032012 | regulation of ARF protein signal transduction | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006897 | endocytosis | TAS | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0030155 | regulation of cell adhesion | IBA | biological_process |
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IBA | molecular_function |