Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STXB1_HUMAN
Description:syntaxin binding protein 1 [Source:HGNC Symbol;Acc:11444]
Location:chr9 q34.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S306QEVTRsLKDFSPKCgRegPhos
S306QEVTRsLKDFSPKCaRegPhos
S146ESQVYsLDSADRegPhos
S306QEVTRsLKDFSPKCbRegPhos
S594DEEIHPRD; phosphoELM
T107AHVFFtDSCPDRegPhos
S313KDFSSsKRMNTPRKCAHPRD
T455IVTDStLRRRSSec1PhosphoSitePlus
Y473ISEQTyQLSRWSec1PhosphoSitePlus
Y145YESQVySLDSARegPhos
S590PDFREsSRVSFHPRD
S142FLPYEsQVYSLRegPhos
S313KDFSSsKRMNTPKCaRegPhos
S313KDFSSsKRMNTPKCbRegPhos
S594DEEISs_____PhosphoSitePlus
S313KDFSSsKRMNTPRKCBHPRD
S313KDFSSsKRMNTPRKCGHPRD
S313KDFSSsKRMNTPKCgRegPhos
Y337KKMPQyQKELSSec1; YlbD_coatPhosphoSitePlus
T489DIMEDtIEDKLSec1PhosphoSitePlus
T574STHILtPQKLLSec1PhosphoSitePlus
T346LSKYStHLHLARegPhos
S507ISTRSsASFSTRegPhos
S509TRSSAsFSTTARegPhos
S454PIVTDsTLRRRSec1PhosphoSitePlus
S306QEVTRsLKDFSPRKCGHPRD
S306QEVTRsLKDFSPRKCBHPRD
S306QEVTRsLKDFSPRKCAHPRD
S345ELSKYsTHLHLRegPhos
Y473ISEQTyQLSRWRegPhos
S509TRSSAsFSTTASec1PhosphoSitePlus

Dephosphorylation site
STXB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362396S593NTCGAOvarian Cancer21720365, 18772890
ENSP00000362396D436NCOSMICMelanoma21499247
ENSP00000362396S593NCOSMICOvarian Cancer21720365
ENSP00000362399D436NCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000362396Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
STXB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSTXB1_HUMANkinase -> substrateRegPhos
KPCB_HUMANSTXB1_HUMANkinase -> substrateHPRD
KPCA_HUMANSTXB1_HUMANkinase -> substrateHPRD
KPCG_HUMANSTXB1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04721Synaptic vesicle cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0014047glutamate secretionTASbiological_process
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0019905syntaxin bindingIEAmolecular_function
GO:0007412axon target recognitionIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0017075syntaxin-1 bindingISSmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0050796regulation of insulin secretionTASbiological_process
GO:0010807regulation of synaptic vesicle primingISSbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0007269neurotransmitter secretionIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0060292long term synaptic depressionIEAbiological_process
GO:0043234protein complexISScellular_component
GO:0000149SNARE bindingIEAmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0050821protein stabilizationIEAbiological_process
GO:0016188synaptic vesicle maturationIEAbiological_process
GO:0017075syntaxin-1 bindingIEAmolecular_function
GO:0032229negative regulation of synaptic transmission, GABAIEAbiological_process
GO:0042802identical protein bindingISSmolecular_function
GO:0010807regulation of synaptic vesicle primingIEAbiological_process
GO:0031091platelet alpha granuleIDAcellular_component
GO:0002576platelet degranulationIMPbiological_process
GO:0007412axon target recognitionISSbiological_process
GO:0006887exocytosisIEAbiological_process
GO:0070527platelet aggregationIMPbiological_process
GO:0032229negative regulation of synaptic transmission, GABAISSbiological_process
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0019905syntaxin bindingIPImolecular_function
GO:0000149SNARE bindingISSmolecular_function
GO:0006904vesicle docking involved in exocytosisIEAbiological_process
GO:0016188synaptic vesicle maturationISSbiological_process
GO:0045956positive regulation of calcium ion-dependent exocyIEAbiological_process
GO:0005739mitochondrionISScellular_component
GO:0005886plasma membraneISScellular_component
GO:0015031protein transportIEAbiological_process
GO:0007269neurotransmitter secretionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0007274neuromuscular synaptic transmissionIEAbiological_process


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