Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRP3_HUMAN
Description:RAS guanyl releasing protein 3 (calcium and DAG-regulated) [Source:HGNC Symbol;Acc:14545]
Location:chr2 p22.3
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T133WMRRVtQRKKVPhosphoSitePlus; HPRD; RegPhos
S638FPKMKsKFHDKPhosphoSitePlus
T133WMRRVtQRKKVPKC_thetaphosphoELM
T133WMRRVtQRKKVPKCt(PKC thetaRegPhos
T610LQRATtSQATQPhosphoSitePlus

Dephosphorylation site
GRP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385886D175NCOSMICLung Cancer
ENSP00000384192D175NCOSMICLung Cancer
ENSP00000384192F452LCOSMICOvarian Cancer21720365
ENSP00000384192F452LTCGAOvarian Cancer21720365, 18772890
ENSP00000384192T506ACOSMICLung Cancer20668451
ENSP00000384192N283SCOSMICOvarian Cancer21720365
ENSP00000385886N283SCOSMICOvarian Cancer21720365
ENSP00000385886T506ACOSMICLung Cancer20668451
ENSP00000385886F452LTCGAOvarian Cancer21720365, 18772890
ENSP00000384192I448LBIOMARTGastric Cancer21930507, 21930502
ENSP00000385886F452LCOSMICOvarian Cancer21720365

Differential expressed protein
GRP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCB_HUMANGRP3_HUMANkinase -> substrateNetPath
ZAGL2_HUMANGRP3_HUMANkinase -> substrateRegPhos
KPCT_HUMANGRP3_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
PLCG2_HUMANGRP3_HUMANotherKEGG
GRP3_HUMANRASH_HUMANotherKEGG
SOS1_HUMANGRP3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04662B cell receptor signaling pathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032045guanyl-nucleotide exchange factor complexIEAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0032854positive regulation of Rap GTPase activityIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005088Ras guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005509calcium ion bindingNASmolecular_function
GO:0004871signal transducer activityTASmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005085guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005887integral to plasma membraneNAScellular_component
GO:0019900kinase bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0017016Ras GTPase bindingIEAmolecular_function
GO:0043087regulation of GTPase activityIEAbiological_process
GO:0019992diacylglycerol bindingNASmolecular_function
GO:0046582Rap GTPase activator activityIDAmolecular_function
GO:0000165MAPK cascadeNASbiological_process


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