| UniProt/SwissProt ID: | PP2AB_HUMAN |
| Description: | protein phosphatase 2, catalytic subunit, beta isozyme [Source:HGNC Symbol;Acc:9300] |
| Location: | chr8 p12 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y284 | DDTLKySFLQF | PhosphoSitePlus | |
| Y86 | LFMGDyVDRGY | Metallophos | PhosphoSitePlus |
| Y248 | LVMEGyNWCHD | PhosphoSitePlus | |
| T304 | HVTRRtPDYFL | PhosphoSitePlus | |
| Y91 | YVDRGyYSVET | Metallophos | PhosphoSitePlus |
| Y92 | VDRGYySVETV | Metallophos | PhosphoSitePlus |
| Y265 | FSAPNyCYRCG | PhosphoSitePlus | |
| Dephosphorylation site |
| PP2AB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000384493 | *310S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000221138 | *310S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000384493 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Down | 0.28 | 16788983 |
| Hyperphosphorylation site |
| PP2AB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PP2AB_HUMAN | TAU_HUMAN | phosphatase -> substrate | HPRD |
| PP2AB_HUMAN | DCE1_HUMAN | phosphatase -> substrate | HPRD |
| PP2AB_HUMAN | KPCB_HUMAN | phosphatase -> substrate | HPRD |
| PP2AB_HUMAN | TRI18_HUMAN | phosphatase -> substrate | HPRD |
| PP2AB_HUMAN | PACS1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04728 | Dopaminergic synapse |
| hsa04114 | Oocyte meiosis |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa05160 | Hepatitis C |
| hsa04310 | Wnt signaling pathway |
| hsa04730 | Long-term depression |
| hsa04350 | TGF-beta signaling pathway |
| hsa03015 | mRNA surveillance pathway |
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | IEA | biological_process |
| GO:0042542 | response to hydrogen peroxide | IEA | biological_process |
| GO:0000922 | spindle pole | IEA | cellular_component |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0042221 | response to chemical stimulus | IEA | biological_process |
| GO:0000159 | protein phosphatase type 2A complex | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0046677 | response to antibiotic | IEA | biological_process |
| GO:0000775 | chromosome, centromeric region | IEA | cellular_component |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0008022 | protein C-terminus binding | IEA | molecular_function |
| GO:0010468 | regulation of gene expression | IEA | biological_process |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0046580 | negative regulation of Ras protein signal transduc | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |