Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PP2AB_HUMAN
Description:protein phosphatase 2, catalytic subunit, beta isozyme [Source:HGNC Symbol;Acc:9300]
Location:chr8 p12
Node attribute:phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y284DDTLKySFLQFPhosphoSitePlus
Y86LFMGDyVDRGYMetallophosPhosphoSitePlus
Y248LVMEGyNWCHDPhosphoSitePlus
T304HVTRRtPDYFLPhosphoSitePlus
Y91YVDRGyYSVETMetallophosPhosphoSitePlus
Y92VDRGYySVETVMetallophosPhosphoSitePlus
Y265FSAPNyCYRCGPhosphoSitePlus

Dephosphorylation site
PP2AB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384493*310SCOSMICOvarian Cancer21720365
ENSP00000221138*310SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000384493papillary thyroid carcinomaNormal vs. CancertissueDown0.2816788983

Hyperphosphorylation site
PP2AB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PP2AB_HUMANTAU_HUMANphosphatase -> substrateHPRD
PP2AB_HUMANDCE1_HUMANphosphatase -> substrateHPRD
PP2AB_HUMANKPCB_HUMANphosphatase -> substrateHPRD
PP2AB_HUMANTRI18_HUMANphosphatase -> substrateHPRD
PP2AB_HUMANPACS1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04728Dopaminergic synapse
hsa04114Oocyte meiosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05160Hepatitis C
hsa04310Wnt signaling pathway
hsa04730Long-term depression
hsa04350TGF-beta signaling pathway
hsa03015mRNA surveillance pathway
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043161proteasomal ubiquitin-dependent protein catabolic IEAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0000922spindle poleIEAcellular_component
GO:0016787hydrolase activityIEAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0042221response to chemical stimulusIEAbiological_process
GO:0000159protein phosphatase type 2A complexIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0046677response to antibioticIEAbiological_process
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0010468regulation of gene expressionIEAbiological_process
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0046580negative regulation of Ras protein signal transducIEAbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23