Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DVL2_HUMAN
Description:dishevelled, dsh homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:3086]
Location:chr17 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T153EPETEtESVVSPhosphoSitePlus
T224RFSSStEQSSADishevelledPhosphoSitePlus
S142HPNVSsSHENLPhosphoSitePlus
S286SIVGQsNERGDPDZ; Shufflon_NPhosphoSitePlus
S230EQSSAsRLLKRHPRD
S228STEQSsASRLLDishevelledPhosphoSitePlus
S170RRRDSsEHGAGDishevelledPhosphoSitePlus
T364PQAYFtLPRNEPhosphoSitePlus
S729AMGNPsEFFVDPhosphoSitePlus
S211TSLGDsDEEDTHPRD
S211TSLGDsDEEDTDishevelledPhosphoSitePlus
S169PRRRDsSEHGADishevelledPhosphoSitePlus
S222MSRFSsSTEQSHPRD
S227SSTEQsSASRLHPRD; phosphoELM
S158TESVVsLRRERPhosphoSitePlus
T151NLEPEtETESVPhosphoSitePlus
S143PNVSSsHENLEPhosphoSitePlus
Y362PSPQAyFTLPRPhosphoSitePlus
Y18ETKVIyHLDEEDIXPhosphoSitePlus
Y478REARKyASGLLDEPPhosphoSitePlus
Y295GDGGIyIGSIMPDZ; Shufflon_NPhosphoSitePlus
Y27EEETPyLVKIPDIXPhosphoSitePlus
S630SSRGGsLRRGGDsh_CPhosphoSitePlus
S135DSRPPsFHPNVPhosphoSitePlus
S720TASRQsFHMAMDsh_CPhosphoSitePlus
S155ETETEsVVSLRPhosphoSitePlus
S228STEQSsASRLLHPRD; phosphoELM
T206SELEStSLGDSDishevelledPhosphoSitePlus
S196GYESSsTLMTSDishevelledPhosphoSitePlus
Y275LNMEKyNFLGIPDZPhosphoSitePlus
S195AGYESsSTLMTDishevelledPhosphoSitePlus
S626ESEPSsRGGSLDsh_CPhosphoSitePlus
S221TMSRFsSSTEQDishevelledPhosphoSitePlus
Y463VVDWLyHHVEGDEPPhosphoSitePlus
T39PAERItLGDFKDIXPhosphoSitePlus
T14GGVGEtKVIYHDIXPhosphoSitePlus

Dephosphorylation site
DVL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000005340I282TCOSMICRenal Cancer21248752

Differential expressed protein
DVL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DVL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1E_HUMANDVL2_HUMANkinase -> substrateNetPath
KPCB_HUMANDVL2_HUMANkinase -> substrateNetPath
KPCA_HUMANDVL2_HUMANkinase -> substrateNetPath
KPCG_HUMANDVL2_HUMANkinase -> substrateNetPath
KC1D_HUMANDVL2_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa04330Notch signaling pathway
hsa05166HTLV-I infection
hsa04310Wnt signaling pathway
hsa05217Basal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044340canonical Wnt receptor signaling pathway involved IDAbiological_process
GO:0003007heart morphogenesisIBAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0003151outflow tract morphogenesisISSbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0035567non-canonical Wnt receptor signaling pathwayIMPbiological_process
GO:0007379segment specificationISSbiological_process
GO:0060071Wnt receptor signaling pathway, planar cell polariIEAbiological_process
GO:0090179planar cell polarity pathway involved in neural tuIBAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0043507positive regulation of JUN kinase activityIDAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0090103cochlea morphogenesisIEAbiological_process
GO:0035329hippo signaling cascadeTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0045177apical part of cellIBAcellular_component
GO:0061098positive regulation of protein tyrosine kinase actIEAbiological_process
GO:0005886plasma membraneIBAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0034613cellular protein localizationIEAbiological_process
GO:0021535cell migration in hindbrainIBAbiological_process
GO:0022007convergent extension involved in neural plate elonIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0003007heart morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0016055Wnt receptor signaling pathwayIGIbiological_process
GO:0035282segmentationIEAbiological_process
GO:0060071Wnt receptor signaling pathway, planar cell polariIDAbiological_process
GO:0060029convergent extension involved in organogenesisIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0090103cochlea morphogenesisIBAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0030136clathrin-coated vesicleIEAcellular_component
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0001843neural tube closureISSbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0060026convergent extensionIBAbiological_process
GO:0005109frizzled bindingIPImolecular_function
GO:0090179planar cell polarity pathway involved in neural tuIEAbiological_process
GO:0043507positive regulation of JUN kinase activityIEAbiological_process
GO:0043621protein self-associationIEAmolecular_function
GO:0007379segment specificationIEAbiological_process
GO:0005938cell cortexIBAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030136clathrin-coated vesicleIBAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0007507heart developmentISSbiological_process