Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MARK1_HUMAN
Description:MAP/microtubule affinity-regulating kinase 1 [Source:HGNC Symbol;Acc:6896]
Location:chr1 q41
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S649ARRGTsTGIISPhosphoSitePlus; phosphoELM; RegPhos
S219DTFCGsPPYAALKB1RegPhos; SysPTM
S394RSRPSsDLNNSRegPhos
T581YRPGTtQRVPAPhosphoSitePlus
S787FKNIAsKIANEKA1PhosphoSitePlus
S470TVGSKsEMTASPhosphoSitePlus
T215GNKLDtFCGSPHPRD; RegPhos; SysPTM
Y494PSNNVySGGSMPhosphoSitePlus
S475SEMTAsPLVGPPhosphoSitePlus; HPRD; SysPTM
S666VRRDPsEGEASRegPhos
T215GNKLDtFCGSPPkinase_CAMKPhosphoSitePlus; SysPTM
S399SDLNNsTLQSPPhosphoSitePlus; HPRD
S633NGPPAsPSHETPhosphoSitePlus; HPRD; SysPTM
T596AHSIStATPDRPhosphoSitePlus; HPRD; phosphoELM
S679TDTSRsTSGEPPhosphoSitePlus
S423KQRRFsDHAGPPhosphoSitePlus; HPRD; SysPTM
S573TIKDGsEAYRPPhosphoSitePlus
S463ARKLGsTTVGSPhosphoSitePlus
T598SISTAtPDRTRPhosphoSitePlus; phosphoELM
S595SAHSIsTATPDPhosphoSitePlus
S219DTFCGsPPYAAPkinase_CAMKPhosphoSitePlus; SysPTM
T215GNKLDtFCGSPTAO1RegPhos; SysPTM
T215GNKLDtFCGSPLKB1phosphoELM; RegPhos; SysPTM
T5LPTVHPRD; SysPTM
T504MARRNtYVCERPhosphoSitePlus
T580AYRPGtTQRVPPhosphoSitePlus
T5_MSARtPLPTVPhosphoSitePlus; SysPTM
S36PTKSSsRQNIPPhosphoSitePlus
S699DSKPRsLRFTWPhosphoSitePlus
S393QRSRPsSDLNNPhosphoSitePlus; HPRD
T215GNKLDtFCGSPSTK11HPRD; SysPTM
T65YRLQKtIGKGNPkinase_CAMKPhosphoSitePlus
S468STTVGsKSEMTPhosphoSitePlus
S219DTFCGsPPYAAHPRD; RegPhos; SysPTM
T648HARRGtSTGIIHPRD
S590PAASPsAHSISPhosphoSitePlus; phosphoELM
S46PRCRNsITSATPhosphoSitePlus; HPRD; SysPTM
T215GNKLDtFCGSPTAOK1HPRD; SysPTM
T215GNKLDtFCGSPLKB1(STK11RegPhos; SysPTM
S588RVPAAsPSAHSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T400DLNNStLQSPAHPRD
S403NSTLQsPAHLKPhosphoSitePlus; HPRD; RegPhos; SysPTM
S219DTFCGsPPYAASTK11HPRD; SysPTM
S681TSRSTsGEPKEPhosphoSitePlus
Y505ARRNTyVCERTPhosphoSitePlus
S612GSSSRsTFHGEPhosphoSitePlus; phosphoELM

Dephosphorylation site
MARK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355884G378STCGAOvarian Cancer21720365, 18772890
ENSP00000355884P432LCOSMICMelanoma21499247
ENSP00000355884G378SCOSMICOvarian Cancer21720365
ENSP00000355884E758fs*32COSMICLung Cancer16140923
ENSP00000355884Y233CGreenman2007, COSMIC, HPIGastric Cancer17344846, 18428421
ENSP00000355884S447NCOSMICCentral Nervous System Neoplasms18772890
ENSP00000355884L250VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000355884V457LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000355884V457LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000355885L228VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000355884G572SCOSMICOvarian Cancer20826764
ENSP00000355884A77ECOSMICMelanoma21499247
ENSP00000355884N355TGreenman2007, COSMIC, HPIOvarian Cancer17344846, 18428421
ENSP00000355884S447NTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
MARK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MARK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MARK1_HUMANMAP2_HUMANkinase -> substrateRegPhos
STK11_HUMANMARK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANMARK1_HUMANkinase -> substrateRegPhos
MARK1_HUMANMAP4_HUMANkinase -> substrateRegPhos
MARK1_HUMANTAU_HUMANkinase -> substrateRegPhos
TAOK1_HUMANMARK1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
MARK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmISScellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005856cytoskeletonISScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0050321tau-protein kinase activityIEAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0001786phosphatidylserine bindingIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0070300phosphatidic acid bindingIDAmolecular_function
GO:0001764neuron migrationIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0007010cytoskeleton organizationISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0015630microtubule cytoskeletonTAScellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0001764neuron migrationISSbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0050321tau-protein kinase activityISSmolecular_function


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