Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SNRK_HUMAN
Description:SNF related kinase [Source:HGNC Symbol;Acc:30598]
Location:chr3 p22.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S531YHRRKsQGRGSPhosphoSitePlus
S518KMNIAsPGTVHPhosphoSitePlus; HPRD
T173GKKLTtSCGSLLKB1(STK11RegPhos
T380DDLTAtPLSHAPhosphoSitePlus
S569WHRRDsSEGPPPhosphoSitePlus
S536SQGRGsSCSSSPhosphoSitePlus
T172PGKKLtTSCGSPkinase_CAMKPhosphoSitePlus
T173GKKLTtSCGSLLKB1phosphoELM; RegPhos
T619GNPTNtSGTTRPhosphoSitePlus
Y562DSGFTySWHRRPhosphoSitePlus
S537QGRGSsCSSSEPhosphoSitePlus
S390ATVPQsPARAAPhosphoSitePlus; phosphoELM
T173GKKLTtSCGSLRegPhos
S460DKKPMsLSTQVPhosphoSitePlus
T543CSSSEtSDDDSPhosphoSitePlus
T463PMSLStQVVLRPhosphoSitePlus
T173GKKLTtSCGSLSTK11HPRD
S607NAGGGsPSSGSPhosphoSitePlus; HPRD
T157GLVKLtDFGFSPkinase_CAMKPhosphoSitePlus
T617SGGNPtNTSGTPhosphoSitePlus
T623NTSGTtRRCAGPhosphoSitePlus
S174KKLTTsCGSLAPkinase_CAMKPhosphoSitePlus
S570HRRDSsEGPPGPhosphoSitePlus
T173GKKLTtSCGSLPkinase_CAMKPhosphoSitePlus

Dephosphorylation site
SNRK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000401246P748LHPI, COSMICOvarian Cancer17344846
ENSP00000296088A28VCOSMICMelanoma21499247
ENSP00000401246V387FTCGAOvarian Cancer21720365, 18772890
ENSP00000401246A28VCOSMICMelanoma21499247
ENSP00000411375P748LHPI, COSMICOvarian Cancer17344846
ENSP00000411375V387FCOSMICOvarian Cancer21720365
ENSP00000411375V387FTCGAOvarian Cancer21720365, 18772890
ENSP00000296088I765MGreenman2007, COSMIC, HPIBreast Cancer15908952, 17344846, 18428421
ENSP00000401246K738TCOSMICGastric Cancer21097718
ENSP00000296088S541LCOSMICSkin Cancer21984974
ENSP00000296088G611SGreenman2007, COSMIC, HPIOvarian Cancer17344846, 18428421
ENSP00000401246S541LCOSMICSkin Cancer21984974
ENSP00000411375G611SHPI, COSMICOvarian Cancer17344846
ENSP00000411375K738TCOSMICGastric Cancer21097718
ENSP00000401246S541LCOSMICSkin Cancer21984974
ENSP00000401246K738TCOSMICGastric Cancer21097718
ENSP00000411375S541LCOSMICSkin Cancer21984974
ENSP00000401246I765MHPI, COSMICBreast Cancer17344846, 15908952
ENSP00000401246V387FCOSMICOvarian Cancer21720365
ENSP00000296088K738TCOSMICGastric Cancer21097718
ENSP00000296088V387FCOSMICOvarian Cancer21720365
ENSP00000401246G611SHPI, COSMICOvarian Cancer17344846
ENSP00000296088P748LGreenman2007, COSMIC, HPIOvarian Cancer17344846, 18428421
ENSP00000411375I765MHPI, COSMICBreast Cancer17344846, 15908952
ENSP00000296088V387FTCGAOvarian Cancer21720365, 18772890
ENSP00000411375A28VCOSMICMelanoma21499247

Differential expressed protein
SNRK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SNRK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SNRK_HUMANRPC4_HUMANkinase -> substrateRobert H Newman (2013)
SNRK_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
SNRK_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
SNRK_HUMANZN606_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSNRK_HUMANkinase -> substrateRegPhos
SNRK_HUMANJADE1_HUMANkinase -> substrateRobert H Newman (2013)
SNRK_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANSNRK_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
SNRK_HUMANRGS14_HUMANkinase -> substrateRobert H Newman (2013)
SNRK_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SNRK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0030099myeloid cell differentiationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function


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