| UniProt/SwissProt ID: | TFE3_HUMAN |
| Description: | transcription factor binding to IGHM enhancer 3 [Source:HGNC Symbol;Acc:11752] |
| Location: | chrX p11.23 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S560 | VSPAVsKASSR | HPRD | |
| S542 | SGGALsPLRAA | HPRD | |
| S548 | PLRAAsDPLLS | HPRD | |
| S101 | SSAGGsRTPAM | PhosphoSitePlus | |
| S560 | VSPAVsKASSR | DUF3371 | PhosphoSitePlus |
| S554 | DPLLSsVSPAV | HPRD | |
| S246 | GSAPNsPMALL | HPRD | |
| S568 | SSRRSsFSMEE | HPRD | |
| S568 | SSRRSsFSMEE | DUF3371 | PhosphoSitePlus |
| T236 | PEAAHtTGPTG | HPRD | |
| S556 | LLSSVsPAVSK | HPRD | |
| S553 | SDPLLsSVSPA | HPRD | |
| S542 | SGGALsPLRAA | DUF3371 | PhosphoSitePlus |
| T217 | ASQALtPPPGP | HPRD | |
| S567 | ASSRRsSFSME | DUF3371 | PhosphoSitePlus |
| S257 | TIGSSsEKEID | HPRD | |
| S112 | SSSSSsRVLLR | PhosphoSitePlus | |
| S556 | LLSSVsPAVSK | DUF3371 | PhosphoSitePlus |
| S548 | PLRAAsDPLLS | DUF3371 | PhosphoSitePlus |
| S575 | SMEEEs_____ | DUF3371 | PhosphoSitePlus |
| Dephosphorylation site |
| TFE3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000314129 | A125T | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000314129 | P219L | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TFE3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TFE3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STK11_HUMAN | TFE3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TFE3_HUMAN | PAI1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TFE3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006959 | humoral immune response | ISS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | ISS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0045670 | regulation of osteoclast differentiation | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0044212 | transcription regulatory region DNA binding | ISS | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | ISS | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |