| UniProt/SwissProt ID: | MARK3_HUMAN |
| Description: | MAP/microtubule affinity-regulating kinase 3 [Source:HGNC Symbol;Acc:6897] |
| Location: | chr14 q32.32 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y508 | TRRNTyVCSER | PhosphoSitePlus | |
| Y690 | ANNCDyEQRER | PhosphoSitePlus | |
| T234 | GGKLDtFCGSP | phosphoELM; RegPhos | |
| S469 | GIAPAsPMLGN | PhosphoSitePlus; HPRD | |
| S490 | ERKKSsTVPSS | PhosphoSitePlus | |
| Y340 | MVGMGySQEEI | UBA | PhosphoSitePlus |
| S341 | VGMGYsQEEIQ | UBA | PhosphoSitePlus |
| S643 | SSRNVsAEQKD | PhosphoSitePlus | |
| S568 | STHSIsSAATP | phosphoELM | |
| S376 | LDASDsSSSSN | PhosphoSitePlus | |
| S618 | TRRNMsFRFIK | PhosphoSitePlus | |
| S455 | ISSRKsSGSAV | PhosphoSitePlus; HPRD | |
| T438 | PKRSQtSTADS | PhosphoSitePlus | |
| S657 | EAKPRsLRFTW | PhosphoSitePlus | |
| S442 | KQRRYsDHAGP | phosphoELM; RegPhos; SysPTM | |
| S400 | NSTGQsPHHKV | PhosphoSitePlus; HPRD | |
| S546 | THSISsAATPD | PhosphoSitePlus | |
| S492 | GIAPAsPMLGN | phosphoELM; RegPhos; SysPTM | |
| T397 | DLNNStGQSPH | PhosphoSitePlus; HPRD | |
| S563 | RTPVAsTHSIS | phosphoELM | |
| T576 | ERRTAtYNGPP | PhosphoSitePlus | |
| T614 | LSHEAtPLSQT | phosphoELM | |
| S587 | ASPSLsHEATP | PhosphoSitePlus; HPRD | |
| T491 | RKKSStVPSSN | PhosphoSitePlus | |
| T564 | TASRStFHGQP | PhosphoSitePlus | |
| T536 | IPDQRtPVAST | PhosphoSitePlus; HPRD | |
| S42 | ARCRNsIASCA | PhosphoSitePlus; HPRD | |
| T591 | LSHEAtPLSQT | PhosphoSitePlus | |
| S608 | PPASPsLSHEA | phosphoELM | |
| S419 | KQRRYsDHAGP | PhosphoSitePlus; HPRD | |
| T564 | TPVAStHSISS | phosphoELM | |
| S494 | SSTVPsSNTAS | PhosphoSitePlus; HPRD | |
| T549 | ISSAAtPDRIR | PhosphoSitePlus; HPRD | |
| T572 | ISSAAtPDRIR | phosphoELM | |
| S598 | LSQTRsRGSTN | PhosphoSitePlus; HPRD | |
| S215 | DTFCGsPPYAA | Pkinase | PhosphoSitePlus |
| T211 | GGKLDtFCGSP | Pkinase | PhosphoSitePlus |
| T3 | ___MStRTPLP | PhosphoSitePlus | |
| S601 | TRSRGsTNLFS | PhosphoSitePlus; HPRD | |
| T61 | YRLLKtIGKGN | Pkinase | PhosphoSitePlus |
| S383 | SSSNLsLAKVR | PhosphoSitePlus; HPRD | |
| S540 | RTPVAsTHSIS | PhosphoSitePlus | |
| Y432 | PSVVAyPKRSQ | PhosphoSitePlus | |
| S499 | SSNTAsGGMTR | PhosphoSitePlus | |
| S745 | FKNIAsKIANE | KA1 | PhosphoSitePlus |
| T234 | GGKLDtFCGSP | LKB1(STK11 | RegPhos |
| Y418 | QKQRRySDHAG | PhosphoSitePlus; HPRD | |
| S391 | KVRPSsDLNNS | HPRD | |
| S545 | STHSIsSAATP | PhosphoSitePlus | |
| S377 | DASDSsSSSNL | PhosphoSitePlus; HPRD | |
| T234 | GGKLDtFCGSP | LKB1 | phosphoELM |
| S374 | SELDAsDSSSS | PhosphoSitePlus; HPRD | |
| S238 | DTFCGsPPYAA | phosphoELM; RegPhos; SysPTM | |
| S380 | DSSSSsNLSLA | PhosphoSitePlus; HPRD | |
| S585 | PPASPsLSHEA | PhosphoSitePlus; HPRD | |
| T541 | TPVAStHSISS | PhosphoSitePlus | |
| Y577 | RRTATyNGPPA | PhosphoSitePlus | |
| S619 | RSRNVsAEQKD | HPRD | |
| S511 | NTYVCsERTTA | PhosphoSitePlus | |
| S543 | VASTHsISSAA | PhosphoSitePlus | |
| T530 | MTRRNtYVCSE | phosphoELM | |
| S379 | SDSSSsSNLSL | PhosphoSitePlus | |
| S378 | ASDSSsSSNLS | PhosphoSitePlus | |
| T507 | MTRRNtYVCSE | PhosphoSitePlus | |
| S566 | VASTHsISSAA | phosphoELM | |
| S476 | MLGNAsNPNKA | PhosphoSitePlus; HPRD | |
| S624 | TRSRGsTNLFS | phosphoELM; RegPhos | |
| T61 | YRLLKtIGKGN | HPRD | |
| S606 | NGPPAsPSLSH | phosphoELM | |
| T503 | ASGGMtRRNTY | PhosphoSitePlus | |
| S583 | NGPPAsPSLSH | PhosphoSitePlus; HPRD | |
| S610 | ASPSLsHEATP | phosphoELM | |
| S489 | PERKKsSTVPS | PhosphoSitePlus | |
| Dephosphorylation site |
| MARK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000303698 | E344K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000216288 | E344K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000408092 | E367K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000411397 | E120K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000411397 | E344K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000402104 | E265K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000303698 | *730Y | COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| MARK3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MARK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MARK3_HUMAN | 2A5D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MARK3_HUMAN | CHK2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | MARK3_HUMAN | kinase -> substrate | RegPhos |
| STK11_HUMAN | MARK3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MARK3_HUMAN | MID51_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MARK3_HUMAN | KSR1_HUMAN | kinase -> substrate | RegPhos |
| MARK3_HUMAN | MPIP3_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MARK3_HUMAN | KSR2_HUMAN | kinase -> substrate | RegPhos |
| MARK3_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MARK3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |