Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MELK_HUMAN
Description:maternal embryonic leucine zipper kinase [Source:HGNC Symbol;Acc:16870]
Location:chr9 p13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T167DYHLQtCCGSLPkinasePhosphoSitePlus
T494TDKLMtGVISPPhosphoSitePlus; HPRD; SysPTM
S343SCGQAsATPFTPhosphoSitePlus
S431VYTPKsAVKNEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S335VRLRLsSFSCGPhosphoSitePlus; HPRD
S498MTGVIsPERRCPhosphoSitePlus; HPRD; SysPTM
T446FPEPKtPVNKNPhosphoSitePlus; HPRD; SysPTM
S468RYTTPsKARNQPhosphoSitePlus
T460REILTtPNRYTPhosphoSitePlus; HPRD; SysPTM
S407GVESKsLTPALPhosphoSitePlus
S253PKKRIsMKNLLPkinasePhosphoSitePlus
S486KIPVNsTGTDKHPRD
T539LDKVItVLTRSPhosphoSitePlus
Y427NKENVyTPKSAPhosphoSitePlus
Y88FMVLEyCPGGEPkinasePhosphoSitePlus
T415PALCRtPANKLPhosphoSitePlus
T167DYHLQtCCGSLLKB1(STK11RegPhos
S505ERRCRsVELDLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T345GQASAtPFTDIPhosphoSitePlus
S405SNGVEsKSLTPPhosphoSitePlus
Y4__MKDyDELLKPhosphoSitePlus
Y269MQDYNyPVEWQPhosphoSitePlus
Y163KGNKDyHLQTCPkinasePhosphoSitePlus
Y97GELFDyIISQDPkinasePhosphoSitePlus
S391ATPRTsQFTKYPhosphoSitePlus
T387STGAAtPRTSQPhosphoSitePlus
Y438VKNEEyFMFPEPhosphoSitePlus; HPRD
T398FTKYWtESNGVPhosphoSitePlus
T459KREILtTPNRYPhosphoSitePlus
S171QTCCGsLAYAAPkinasePhosphoSitePlus
T167DYHLQtCCGSLLKB1phosphoELM
T489VNSTGtDKLMTPhosphoSitePlus
T466PNRYTtPSKARPhosphoSitePlus
T428KENVYtPKSAVPhosphoSitePlus
S336RLRLSsFSCGQPhosphoSitePlus; HPRD; phosphoELM
Y367ASDKNyVAGLIPhosphoSitePlus
Y267WIMQDyNYPVEPhosphoSitePlus
S529AKVFGsLERGLPhosphoSitePlus; HPRD; SysPTM
S356KSNNWsLEDVTPhosphoSitePlus; HPRD; SysPTM
T518AHMEEtPKRKGPhosphoSitePlus; HPRD; SysPTM
T409ESKSLtPALCRPhosphoSitePlus
T56LPRIKtEIEALPkinasePhosphoSitePlus
T478QCLKEtPIKIPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S338RLSSFsCGQASPhosphoSitePlus

Dephosphorylation site
MELK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000298048T460MGreenman2007, HPIOvarian Cancer17344846, 18428421

Differential expressed protein
MELK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MELK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK11_HUMANMELK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MELK_HUMANMPIP2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMELK_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
MELK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0061351neural precursor cell proliferationIEAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0030097hemopoiesisISSbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005509calcium ion bindingIDAmolecular_function
GO:0006915apoptotic processIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005938cell cortexIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0061351neural precursor cell proliferationISSbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0008283cell proliferationIDAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008289lipid bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0043065positive regulation of apoptotic processISSbiological_process


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