Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NUAK2_HUMAN
Description:NUAK family, SNF1-like kinase, 2 [Source:HGNC Symbol;Acc:29558]
Location:chr1 q32.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S553ILSSEsFDQLDPhosphoSitePlus
T208GKFLQtFCGSPLKB1phosphoELM
S585LEEPPsEGPGSRegPhos
T208GKFLQtFCGSPLKB1(STK11RegPhos
Y267ISNGAyREPPKPkinase_CAMKPhosphoSitePlus
S435SPIPAsPGQAAPhosphoSitePlus
S386NDMAQsLHSDTRegPhos
S212QTFCGsPLYASRegPhos
T208GKFLQtFCGSPRegPhos
S547AVSEDsILSSEPhosphoSitePlus
S462SGYYSsPEPSEPhosphoSitePlus
S523PTTFGsLDELAPhosphoSitePlus
T208GKFLQtFCGSPPkinase_CAMKPhosphoSitePlus
S377HSLKKsRKENDRegPhos
Y140GDLYDyISERQPkinase_CAMKPhosphoSitePlus
Y131VIVMEyASRGDPkinase_CAMKPhosphoSitePlus
S544PSGAVsEDSILPhosphoSitePlus
S142LYDYIsERQQLPkinase_CAMKPhosphoSitePlus
Y138SRGDLyDYISEPkinase_CAMKPhosphoSitePlus

Dephosphorylation site
NUAK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356125K503RGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000356125G541EGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421

Differential expressed protein
NUAK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NUAK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNUAK2_HUMANkinase -> substrateRegPhos
STK11_HUMANNUAK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
NUAK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0042149cellular response to glucose starvationIDAbiological_process
GO:0030036actin cytoskeleton organizationIDAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function


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