| UniProt/SwissProt ID: | KCND2_HUMAN |
| Description: | potassium voltage-gated channel, Shal-related subfamily, member 2 [Source:HGNC Symbol;Acc:6238] |
| Location: | chr7 q31.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y444 | GSANAyMQSKR | PhosphoSitePlus | |
| S459 | SNQLQsSEDEQ | CaM-KII_group | phosphoELM |
| T537 | RRHKKtFRIPN | DUF3399 | PhosphoSitePlus |
| S438 | IRAAKsGSANA | PhosphoSitePlus | |
| S160 | DTAGEsALPTM | PhosphoSitePlus | |
| S440 | AAKSGsANAYM | PhosphoSitePlus | |
| S552 | GSHQGsIQELS | PhosphoSitePlus | |
| S438 | IRAAKsGSANA | CaM-KII_group | phosphoELM |
| Y134 | IGDCCyEEYKD | PhosphoSitePlus | |
| S260 | YRFVRsVMSII | TM; Ion_trans | PhosphoSitePlus |
| S447 | NAYMQsKRNGL | DUF3399 | PhosphoSitePlus |
| Dephosphorylation site |
| KCND2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000333496 | R562T | COSMIC | Skin Cancer | 21984974 | ENSP00000333496 | R140H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000333496 | I216M | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000333496 | S570F | COSMIC | Skin Cancer | 21984974 | ENSP00000333496 | R140H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000333496 | S468N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000333496 | R533* | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| KCND2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KCND2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC4_HUMAN | KCND2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KCND2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0055085 | transmembrane transport | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0001508 | regulation of action potential | IEA | biological_process |
| GO:0006811 | ion transport | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0043197 | dendritic spine | NAS | cellular_component |
| GO:0051260 | protein homooligomerization | IEA | biological_process |
| GO:0001508 | regulation of action potential | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0005250 | A-type (transient outward) potassium channel activ | IBA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005249 | voltage-gated potassium channel activity | NAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008076 | voltage-gated potassium channel complex | IEA | cellular_component |
| GO:0005216 | ion channel activity | IEA | molecular_function |