Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCND2_HUMAN
Description:potassium voltage-gated channel, Shal-related subfamily, member 2 [Source:HGNC Symbol;Acc:6238]
Location:chr7 q31.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y444GSANAyMQSKRPhosphoSitePlus
S459SNQLQsSEDEQCaM-KII_groupphosphoELM
T537RRHKKtFRIPNDUF3399PhosphoSitePlus
S438IRAAKsGSANAPhosphoSitePlus
S160DTAGEsALPTMPhosphoSitePlus
S440AAKSGsANAYMPhosphoSitePlus
S552GSHQGsIQELSPhosphoSitePlus
S438IRAAKsGSANACaM-KII_groupphosphoELM
Y134IGDCCyEEYKDPhosphoSitePlus
S260YRFVRsVMSIITM; Ion_transPhosphoSitePlus
S447NAYMQsKRNGLDUF3399PhosphoSitePlus

Dephosphorylation site
KCND2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000333496R562TCOSMICSkin Cancer21984974
ENSP00000333496R140HCOSMICOvarian Cancer21720365
ENSP00000333496I216MBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000333496S570FCOSMICSkin Cancer21984974
ENSP00000333496R140HTCGAOvarian Cancer21720365, 18772890
ENSP00000333496S468NCOSMICHead and Neck Cancer21798893
ENSP00000333496R533*COSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
KCND2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KCND2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC4_HUMANKCND2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KCND2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0055085transmembrane transportIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0001508regulation of action potentialIEAbiological_process
GO:0006811ion transportIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0043197dendritic spineNAScellular_component
GO:0051260protein homooligomerizationIEAbiological_process
GO:0001508regulation of action potentialTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0005250A-type (transient outward) potassium channel activIBAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0005249voltage-gated potassium channel activityNASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008076voltage-gated potassium channel complexIEAcellular_component
GO:0005216ion channel activityIEAmolecular_function


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