| UniProt/SwissProt ID: | KCC1A_HUMAN |
| Description: | calcium/calmodulin-dependent protein kinase I [Source:HGNC Symbol;Acc:1459] |
| Location: | chr3 p25.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T177 | GSVLStACGTP | CaMK1a | RegPhos |
| T177 | GSVLStACGTP | CaM-KI_group | phosphoELM |
| T177 | GSVLStACGTP | CaM-KI_alpha | phosphoELM |
| T177 | GSVLStACGTP | CAMKK2 | HPRD |
| Y20 | DIRDIyDFRDV | Pkinase_CAMK | PhosphoSitePlus |
| T177 | GSVLStACGTP | CaMK1_group | RegPhos |
| T177 | GSVLStACGTP | CaMKK1 | RegPhos |
| T177 | GSVLStACGTP | CaMKK2 | RegPhos |
| Y235 | ILKAEyEFDSP | Pkinase_CAMK | PhosphoSitePlus |
| Y131 | LDAVKyLHDLG | Pkinase_CAMK | PhosphoSitePlus |
| T177 | GSVLStACGTP | Pkinase_CAMK | PhosphoSitePlus |
| T177 | GSVLStACGTP | CCDPK | RegPhos |
| T177 | GSVLStACGTP | CAMK1 | HPRD |
| S176 | PGSVLsTACGT | Pkinase_CAMK | PhosphoSitePlus |
| Dephosphorylation site |
| KCC1A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000256460 | P217S | Greenman2007 | Skin Cancer | 17344846, 18428421 |
| Differential expressed protein |
| KCC1A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KCC1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC1A_HUMAN | IF4G3_HUMAN | kinase -> substrate | HPRD |
| KKCC2_HUMAN | KCC1A_HUMAN | kinase -> substrate | HPRD |
| KCC1A_HUMAN | NOS1_HUMAN | kinase -> substrate | HPRD |
| KCC1A_HUMAN | SYN1_HUMAN | kinase -> substrate | HPRD |
| KCC4_HUMAN | KCC1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC1A_HUMAN | KCC1A_HUMAN | kinase -> substrate | HPRD |
| KCC1A_HUMAN | HDAC5_HUMAN | kinase -> substrate | HPRD |
| KCC1A_HUMAN | ATF1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KCC1A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043393 | regulation of protein binding | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0051835 | positive regulation of synapse structural plastici | IMP | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0051147 | regulation of muscle cell differentiation | IDA | biological_process |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0004683 | calmodulin-dependent protein kinase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0046827 | positive regulation of protein export from nucleus | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051149 | positive regulation of muscle cell differentiation | IMP | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0032880 | regulation of protein localization | IDA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0010976 | positive regulation of neuron projection developme | IDA | biological_process |
| GO:0071902 | positive regulation of protein serine/threonine ki | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004683 | calmodulin-dependent protein kinase activity | ISS | molecular_function |
| GO:0060999 | positive regulation of dendritic spine development | IMP | biological_process |