| UniProt/SwissProt ID: | SPRE_HUMAN |
| Description: | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) [Source:HGNC Symbol;Acc:11257] |
| Location: | chr2 p13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S213 | LARETsVDPDM | CaMK2g | RegPhos |
| S40 | SVLVLsARNDE | adh_short | PhosphoSitePlus |
| S213 | LARETsVDPDM | CCDPK | phosphoELM; RegPhos |
| S213 | LARETsVDPDM | PhosphoSitePlus | |
| T22 | RGFGRtLAPLL | adh_short | PhosphoSitePlus |
| S213 | LARETsVDPDM | CAMK2G | HPRD |
| S35 | LLSPGsVLVLS | adh_short | PhosphoSitePlus |
| S32 | LASLLsPGSVL | adh_short | PhosphoSitePlus |
| S213 | LARETsVDPDM | CaMK2_group | RegPhos |
| Dephosphorylation site |
| SPRE_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000234454 | V214M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000234454 | K226* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000234454 | V214M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000234454 | K226* | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000234454 | Breast Cancer | Metastasis | tissue | Up | 2.6 | 19053527 | ENSP00000234454 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.6 | 20739354 | ENSP00000234454 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.6 | 20739354 |
| Hyperphosphorylation site |
| SPRE_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC2G_HUMAN | SPRE_HUMAN | kinase -> substrate | HPRD |
| KCC4_HUMAN | SPRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00790 | Folate biosynthesis |
| hsa01100 | Metabolic pathways |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006809 | nitric oxide biosynthetic process | IDA | biological_process |
| GO:0050661 | NADP binding | TAS | molecular_function |
| GO:0050999 | regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004033 | aldo-keto reductase (NADP) activity | TAS | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0004757 | sepiapterin reductase activity | ISS | molecular_function |
| GO:0006729 | tetrahydrobiopterin biosynthetic process | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0055114 | oxidation-reduction process | TAS | biological_process |
| GO:0046209 | nitric oxide metabolic process | TAS | biological_process |