Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPRE_HUMAN
Description:sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) [Source:HGNC Symbol;Acc:11257]
Location:chr2 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S213LARETsVDPDMCaMK2gRegPhos
S40SVLVLsARNDEadh_shortPhosphoSitePlus
S213LARETsVDPDMCCDPKphosphoELM; RegPhos
S213LARETsVDPDMPhosphoSitePlus
T22RGFGRtLAPLLadh_shortPhosphoSitePlus
S213LARETsVDPDMCAMK2GHPRD
S35LLSPGsVLVLSadh_shortPhosphoSitePlus
S32LASLLsPGSVLadh_shortPhosphoSitePlus
S213LARETsVDPDMCaMK2_groupRegPhos

Dephosphorylation site
SPRE_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000234454V214MTCGAOvarian Cancer21720365, 18772890
ENSP00000234454K226*COSMICOvarian Cancer21720365
ENSP00000234454V214MCOSMICOvarian Cancer21720365
ENSP00000234454K226*TCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000234454Breast CancerMetastasistissueUp2.619053527
ENSP00000234454Breast CancerNormal vs. CancertissueUp0.620739354
ENSP00000234454Breast CancerNormal vs. CancertissueUp0.620739354

Hyperphosphorylation site
SPRE_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2G_HUMANSPRE_HUMANkinase -> substrateHPRD
KCC4_HUMANSPRE_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00790Folate biosynthesis
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006809nitric oxide biosynthetic processIDAbiological_process
GO:0050661NADP bindingTASmolecular_function
GO:0050999regulation of nitric-oxide synthase activityTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0004033aldo-keto reductase (NADP) activityTASmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0004757sepiapterin reductase activityISSmolecular_function
GO:0006729tetrahydrobiopterin biosynthetic processTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0008152metabolic processIEAbiological_process
GO:0055114oxidation-reduction processTASbiological_process
GO:0046209nitric oxide metabolic processTASbiological_process


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