Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DHPR_HUMAN
Description:quinoid dihydropteridine reductase [Source:HGNC Symbol;Acc:9752]
Location:chr4 p15.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T184AVLPVtLDTPMPhosphoSitePlus
T203DFSSWtPLEFLPhosphoSitePlus
S223GKNRPsSGSLICaM-KII_groupphosphoELM
Y16RRVLVyGGRGAadh_shortPhosphoSitePlus
S193PMNRKsMPEADPhosphoSitePlus
T133EGGLLtLAGAKadh_shortPhosphoSitePlus
T123SSHLAtKHLKEadh_shortPhosphoSitePlus
T133EGGLLtLAGAKHPRD
S223GKNRPsSGSLIPhosphoSitePlus
T187PVTLDtPMNRKPhosphoSitePlus

Dephosphorylation site
DHPR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000281243K79NCOSMICOvarian Cancer21720365
ENSP00000281243A5VCOSMICHead and Neck Cancer21798893
ENSP00000281243A91VCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000281243Hepatocellular CarcinomaNormal vs. Cancercell lineUp5.518646787
ENSP00000281243Renal CancerNormal vs. CancertissueDown19164279

Hyperphosphorylation site
DHPR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC4_HUMANDHPR_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DHPR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044281small molecule metabolic processTASbiological_process
GO:0035690cellular response to drugIEAbiological_process
GO:0006729tetrahydrobiopterin biosynthetic processIEAbiological_process
GO:0016491oxidoreductase activityIEAmolecular_function
GO:00041556,7-dihydropteridine reductase activityEXPmolecular_function
GO:0008152metabolic processIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0033762response to glucagon stimulusIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0010288response to lead ionIEAbiological_process
GO:0006520cellular amino acid metabolic processTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0001889liver developmentIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006559L-phenylalanine catabolic processIEAbiological_process
GO:0009055electron carrier activityTASmolecular_function
GO:0006559L-phenylalanine catabolic processTASbiological_process
GO:0070404NADH bindingIEAmolecular_function
GO:0010044response to aluminum ionIEAbiological_process
GO:0051066dihydrobiopterin metabolic processTASbiological_process
GO:0070402NADPH bindingIEAmolecular_function
GO:00041556,7-dihydropteridine reductase activityIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0042803protein homodimerization activityIEAmolecular_function


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