Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HDAC4_HUMAN
Description:histone deacetylase 4 [Source:HGNC Symbol;Acc:14063]
Location:chr2 q37.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1057EAETVtAMASLArb2PhosphoSitePlus
S632LSRAQsSPASACaMK4RegPhos; SysPTM
S467LGRTQsAPLPQCAMK4HPRD
S339VAREGsAAPLPPhosphoSitePlus
S744LGSLAsVFVRLHist_deacetylPhosphoSitePlus
S246LRKTAsEPNLKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S565QEPIEsDEEEAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S632LSRAQsSPASACaM-KIVphosphoELM; SysPTM
Y540LLDEPyLDRLPPhosphoSitePlus
S58LDHQFsLPVAEPhosphoSitePlus
S741KKLLGsLASVFHist_deacetylPhosphoSitePlus
S467LGRTQsAPLPQCaMK4RegPhos
T465RPLGRtQSAPLPhosphoSitePlus
S210KTQHSsLDQSSPhosphoSitePlus
S632LSRAQsSPASACAMK4HPRD; SysPTM
S350LYTSPsLPNITPhosphoSitePlus
S168ESAVAsTEVKMPhosphoSitePlus
S467LGRTQsAPLPQCaM-KIVphosphoELM
S1025VMEIHsKYWRCArb2PhosphoSitePlus
S633SRAQSsPASATPhosphoSitePlus; HPRD; phosphoELM
S636QSSPAsATFPVPhosphoSitePlus; HPRD; phosphoELM
S265VAERRsSPLLRPhosphoSitePlus; HPRD
S298SSAPGsGPSSPPhosphoSitePlus
S467LGRTQsAPLPQPhosphoSitePlus; phosphoELM
S400PYLSTsPLERDPhosphoSitePlus
S348LPLYTsPSLPNPhosphoSitePlus
T278DGPVVtALKKRPhosphoSitePlus; HPRD; SysPTM
S266AERRSsPLLRRPhosphoSitePlus; HPRD
S1061VTAMAsLSVGVPhosphoSitePlus
S302GSGPSsPNNSSPhosphoSitePlus
S632LSRAQsSPASAPhosphoSitePlus; phosphoELM; SysPTM
T638SPASAtFPVSVPhosphoSitePlus; HPRD; phosphoELM
S246LRKTAsEPNLKCaMK4RegPhos

Dephosphorylation site
HDAC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264606P727RSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000264606Q116*COSMICMelanoma
ENSP00000264606A325TCOSMICMelanoma
ENSP00000264606H193PCOSMICOvarian Cancer21720365
ENSP00000264606G887VCOSMICHead and Neck Cancer21798893
ENSP00000264606P363LCOSMICSkin Cancer21984974

Differential expressed protein
HDAC4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HDAC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANHDAC4_HUMANkinase -> substrateRegPhos
KCC4_HUMANHDAC4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa05034Alcoholism
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0097372NAD-dependent histone deacetylase activity (H3-K18IEAmolecular_function
GO:0000118histone deacetylase complexIDAcellular_component
GO:0010882regulation of cardiac muscle contraction by calciuIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0010832negative regulation of myotube differentiationIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031594neuromuscular junctionIEAcellular_component
GO:0016575histone deacetylationIDAbiological_process
GO:0016568chromatin modificationIEAbiological_process
GO:0002076osteoblast developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0045820negative regulation of glycolysisIEAbiological_process
GO:0014898cardiac muscle hypertrophy in response to stressTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0004407histone deacetylase activityIDAmolecular_function
GO:0033558protein deacetylase activityIEAmolecular_function
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0014894response to denervation involved in regulation of IEAbiological_process
GO:0017053transcriptional repressor complexIDAcellular_component
GO:0042641actomyosinIEAcellular_component
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0042113B cell activationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030183B cell differentiationTASbiological_process
GO:0033235positive regulation of protein sumoylationIDAbiological_process
GO:0070932histone H3 deacetylationIDAbiological_process
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 IEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0046970NAD-dependent histone deacetylase activity (H4-K16IEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0030955potassium ion bindingIDAmolecular_function
GO:0031672A bandIEAcellular_component
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0043393regulation of protein bindingIMPbiological_process
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0070555response to interleukin-1IMPbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0007399nervous system developmentTASbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0070933histone H4 deacetylationIDAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0070491repressing transcription factor bindingIPImolecular_function
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0034983peptidyl-lysine deacetylationIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIMPbiological_process
GO:0030017sarcomereIEAcellular_component
GO:0051153regulation of striated muscle cell differentiationIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0006338chromatin remodelingIDAbiological_process
GO:0032041NAD-dependent histone deacetylase activity (H3-K14IEAmolecular_function
GO:0030018Z discIEAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0048742regulation of skeletal muscle fiber developmentIEAbiological_process