Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DVL3_HUMAN
Description:dishevelled, dsh homolog 3 (Drosophila) [Source:HGNC Symbol;Acc:3087]
Location:chr3 q27.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S612HTTRSsLRGPRDsh_CPhosphoSitePlus
S700TASRQsFRMAMDsh_CPhosphoSitePlus
S204SRFSSsTEQSSDishevelledPhosphoSitePlus
T608SESDHtTRSSLDsh_CPhosphoSitePlus
T346PRGCFtLPRSEPhosphoSitePlus
S596PKAGDsKSGGSDsh_CPhosphoSitePlus
S41VLQRPsYKFFFDIXPhosphoSitePlus
S244TDSTMsLNIITPhosphoSitePlus
S203TSRFSsSTEQSDishevelledPhosphoSitePlus
S125HAGGGsQENLDPhosphoSitePlus
S192TSFFDsDEDDSDishevelledPhosphoSitePlus
Y257LNMEKyNFLGIPDZPhosphoSitePlus
S208SSTEQsSASRLDishevelledPhosphoSitePlus
S202STSRFsSSTEQDishevelledPhosphoSitePlus
T609ESDHTtRSSLRDsh_CPhosphoSitePlus
S603SGGSGsESDHTDsh_CPhosphoSitePlus
S192TSFFDsDEDDSHPRD; phosphoELM
S48KFFFKsMDDDFDIXPhosphoSitePlus
S268SIVGQsNERGDPDZPhosphoSitePlus
S209STEQSsASRLMDishevelledPhosphoSitePlus

Dephosphorylation site
DVL3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000316054R168QTCGAOvarian Cancer21720365, 18772890
ENSP00000316054R168QCOSMICOvarian Cancer21720365
ENSP00000316054D94VCOSMICHepatocellular Carcinoma21822264
ENSP00000316054R216TSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
DVL3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DVL3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MARK2_HUMANDVL3_HUMANkinase -> substrateNetPath
KC1D_HUMANDVL3_HUMANkinase -> substrateNetPath
KC1E_HUMANDVL3_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway
hsa05200Pathways in cancer
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa05166HTLV-I infection
hsa05217Basal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005109frizzled bindingIPImolecular_function
GO:0003148outflow tract septum morphogenesisIEAbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0005938cell cortexIBAcellular_component
GO:0005102receptor bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0035567non-canonical Wnt receptor signaling pathwayIMPbiological_process
GO:0090103cochlea morphogenesisIEAbiological_process
GO:0038031non-canonical Wnt receptor signaling pathway via JIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0003007heart morphogenesisIEAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0090179planar cell polarity pathway involved in neural tuIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0060071Wnt receptor signaling pathway, planar cell polariIDAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0016055Wnt receptor signaling pathwayIDAbiological_process
GO:0060026convergent extensionIBAbiological_process
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0043507positive regulation of JUN kinase activityIMPbiological_process
GO:0042493response to drugIEAbiological_process
GO:0008013beta-catenin bindingIDAmolecular_function


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