Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PER2_HUMAN
Description:period circadian clock 2 [Source:HGNC Symbol;Acc:8846]
Location:chr2 q37.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T781PGLRNtSGIDSPhosphoSitePlus
S662PGKAEsVASLTPhosphoSitePlus; RegPhos
S668VASLTsQCSYSCSNK1EHPRD
S1109GSIDSsENNHKPeriod_CPhosphoSitePlus
S810RDSSEsTGSGGPhosphoSitePlus
S696VEDAAsGPESLRegPhos
S977AMGRAsPPLFQCSNK1DHPRD
S700ASGPEsLDCLARegPhos
S782GLRNTsGIDSPPhosphoSitePlus
S714LACGLsQEKEPRegPhos
S540EQKKKsVTEMQRegPhos
S668VASLTsQCSYSPhosphoSitePlus
S533HYSHEsGEQKKRegPhos
S665AESVAsLTSQCPhosphoSitePlus
S945EMASAsQPEFPRegPhos
S530NRSHYsHESGERegPhos
S1108FGSIDsSENNHPeriod_CPhosphoSitePlus
S977AMGRAsPPLFQRegPhos
S766YLQERsKGQPSRegPhos
S662PGKAEsVASLTCK1e(CK1 epsilonRegPhos
T864FPAPGtVAAPPRegPhos
S665AESVAsLTSQCCSNK1EHPRD
S662PGKAEsVASLTCK1eRegPhos
S786TSGIDsPWKKTPhosphoSitePlus
S527KTKNRsHYSHERegPhos
S977AMGRAsPPLFQCK1dRegPhos
S674QCSYSsTIVHVCSNK1EHPRD
S771SKGQPsERTAPRegPhos
S1105SKYFGsIDSSEPeriod_CPhosphoSitePlus
S1124TGMEEsEHFIKRegPhos
S662PGKAEsVASLTCK1_epsilonphosphoELM
S662PGKAEsVASLTCSNK1EHPRD
S671LTSQCsYSSTICSNK1EHPRD

Dephosphorylation site
PER2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254657K553RCOSMICOvarian Cancer21720365
ENSP00000254657Y1102*COSMICHead and Neck Cancer21798897
ENSP00000254657L823VSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
PER2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PER2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1E_HUMANPER2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1D_HUMANPER2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPER2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa05202Transcriptional misregulation in cancer
hsa04710Circadian rhythm - mammal

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0000988protein binding transcription factor activityIEAmolecular_function
GO:0007623circadian rhythmIEAbiological_process


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