| UniProt/SwissProt ID: | TFAM_HUMAN |
| Description: | transcription factor A, mitochondrial [Source:HGNC Symbol;Acc:11741] |
| Location: | chr10 q21.1 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S55 | PKKPVsSYLRF | HPRD | |
| T122 | FKEQLtPSQIM | PhosphoSitePlus | |
| S56 | KKPVSsYLRFS | HPRD | |
| S55 | PKKPVsSYLRF | HMG_box | PhosphoSitePlus |
| S193 | NWKNLsDSEKE | HMG_box | PhosphoSitePlus |
| S128 | PSQIMsLEKEI | PhosphoSitePlus | |
| S124 | EQLTPsQIMSL | PhosphoSitePlus | |
| S193 | NWKNLsDSEKE | HPRD; phosphoELM | |
| S195 | KNLSDsEKELY | HMG_box | PhosphoSitePlus |
| Dephosphorylation site |
| TFAM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TFAM_HUMAN do not have mutation site. |
| Differential expressed protein |
| TFAM_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TFAM_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KC1D_HUMAN | TFAM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1E_HUMAN | TFAM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK24_HUMAN | TFAM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GABPA_HUMAN | TFAM_HUMAN | TF -> target gene | TRANSFAC |
| NRF1_HUMAN | TFAM_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TFAM_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070363 | mitochondrial light strand promoter sense binding | IDA | molecular_function |
| GO:0031072 | heat shock protein binding | IEA | molecular_function |
| GO:0006356 | regulation of transcription from RNA polymerase I | TAS | biological_process |
| GO:0006391 | transcription initiation from mitochondrial promot | IDA | biological_process |
| GO:0042645 | mitochondrial nucleoid | IDA | cellular_component |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0006390 | transcription from mitochondrial promoter | IMP | biological_process |
| GO:0033108 | mitochondrial respiratory chain complex assembly | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0005759 | mitochondrial matrix | TAS | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IMP | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008301 | DNA binding, bending | IDA | molecular_function |
| GO:0003682 | chromatin binding | IDA | molecular_function |