| UniProt/SwissProt ID: | PORCN_HUMAN |
| Description: | porcupine homolog (Drosophila) [Source:HGNC Symbol;Acc:17652] |
| Location: | chrX p11.23 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S93 | LCRHSsHRGVF | DUF3311; MBOAT | PhosphoSitePlus |
| S100 | RGVFLsVTILI | MBOAT; TM | PhosphoSitePlus |
| S92 | FLCRHsSHRGV | DUF3311; MBOAT | PhosphoSitePlus |
| Dephosphorylation site |
| PORCN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000322304 | A329T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000322304 | L47W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354978 | G418S | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000354978 | A324T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000354978 | A318T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000446401 | A329T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354978 | L47W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000446401 | L47W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000446401 | G429S | COSMIC | Central Nervous System Neoplasms | ENSP00000322304 | G429S | COSMIC | Central Nervous System Neoplasms | ENSP00000446401 | G147fs*39 | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000322304 | G147fs*39 | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| PORCN_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PORCN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PORCN_HUMAN | JAK1_HUMAN | other | KEGG |
| PORCN_HUMAN | FZD10_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016746 | transferase activity, transferring acyl groups | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030176 | integral to endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0009100 | glycoprotein metabolic process | IEA | biological_process |
| GO:0016740 | transferase activity | IEA | molecular_function |