Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:INGR1_HUMAN
Description:interferon gamma receptor 1 [Source:HGNC Symbol;Acc:5439]
Location:chr6 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S399LNSYHsRNCSEPhosphoSitePlus
S302ETKPEsKYVSLIFNGR1PhosphoSitePlus
S327CEEPLsPATVPIFNGR1PhosphoSitePlus
S289PKSLIsVVRSAIFNGR1PhosphoSitePlus
Y397IALNSyHSRNCPhosphoSitePlus
S396SIALNsYHSRNPhosphoSitePlus
T298SATLEtKPESKIFNGR1PhosphoSitePlus
S383SSSPLsSNQSEPhosphoSitePlus
Y457PTSFGyDKPHVPhosphoSitePlus; HPRD; RegPhos
Y304KPESKyVSLITIFNGR1PhosphoSitePlus
Y457PTSFGyDKPHVJAK1phosphoELM; RegPhos
S306ESKYVsLITSYIFNGR1PhosphoSitePlus
S293ISVVRsATLETIFNGR1PhosphoSitePlus
S310VSLITsYQPFSIFNGR1PhosphoSitePlus
T295VVRSAtLETKPIFNGR1PhosphoSitePlus
T309YVSLItSYQPFIFNGR1PhosphoSitePlus
Y311SLITSyQPFSLIFNGR1PhosphoSitePlus
S369DVVPGsHLTPIRegPhos

Dephosphorylation site
INGR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356713S379CCOSMICHead and Neck Cancer21798897

Differential expressed protein
INGR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
INGR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK1_HUMANINGR1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANINGR1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05152Tuberculosis
hsa05145Toxoplasmosis
hsa05142Chagas disease (American trypanosomiasis)
hsa04630Jak-STAT signaling pathway
hsa05162Measles
hsa05164Influenza A
hsa05140Leishmaniasis
hsa05168Herpes simplex infection
hsa04060Cytokine-cytokine receptor interaction
hsa04650Natural killer cell mediated cytotoxicity
hsa04380Osteoclast differentiation
hsa05132Salmonella infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0019955cytokine bindingIEAmolecular_function
GO:0009615response to virusTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0004906interferon-gamma receptor activityTASmolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process


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