UniProt/SwissProt ID: | I10R1_HUMAN |
Description: | interleukin 10 receptor, alpha [Source:HGNC Symbol;Acc:5964] |
Location: | chr11 q23.3 |
Node attribute: | substrate |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
Y496 | ALAKGyLKQDP | JAK1 | HPRD; RegPhos |
Y496 | ALAKGyLKQDP | PhosphoSitePlus | |
Y446 | VAFQGyLRQTR | Tyk2 | phosphoELM; RegPhos |
Y446 | VAFQGyLRQTR | JAK1 | HPRD; RegPhos |
Y496 | ALAKGyLKQDP | Tyk2 | phosphoELM; RegPhos |
Y446 | VAFQGyLRQTR | PhosphoSitePlus | |
S268 | RKKLPsVLLFK | PhosphoSitePlus | |
Dephosphorylation site |
I10R1_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000227752 | D538H | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000227752 | E168D | COSMIC | Ovarian Cancer | 21720365 |
Differential expressed protein |
I10R1_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
I10R1_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
JAK1_HUMAN | I10R1_HUMAN | kinase -> substrate | RegPhos |
TYK2_HUMAN | I10R1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa05169 | Epstein-Barr virus infection |
hsa05145 | Toxoplasmosis |
hsa05152 | Tuberculosis |
hsa04630 | Jak-STAT signaling pathway |
hsa04060 | Cytokine-cytokine receptor interaction |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0007165 | signal transduction | TAS | biological_process |
GO:0005886 | plasma membrane | TAS | cellular_component |
GO:0004872 | receptor activity | TAS | molecular_function |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0004920 | interleukin-10 receptor activity | TAS | molecular_function |
GO:0004871 | signal transducer activity | TAS | molecular_function |
GO:0016021 | integral to membrane | IEA | cellular_component |