| UniProt/SwissProt ID: | STAT2_HUMAN |
| Description: | signal transducer and activator of transcription 2, 113kDa [Source:HGNC Symbol;Acc:11363] |
| Location: | chr12 q13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y690 | QERRKyLKHRL | JAK1 | RegPhos |
| S283 | ELKGLsCLVSY | PhosphoSitePlus | |
| T800 | LRHLNtEPMEI | STAT2_C | PhosphoSitePlus |
| Y690 | QERRKyLKHRL | JAK_group | phosphoELM; RegPhos |
| Y631 | YSVQPyTKEVL | SH2 | PhosphoSitePlus |
| Y833 | TVDEVyVSRPS | STAT2_C | PhosphoSitePlus |
| S287 | LSCLVsYQDDP | PhosphoSitePlus | |
| T597 | KTMSGtFLLRF | SH2 | PhosphoSitePlus |
| Y690 | QERRKyLKHRL | PhosphoSitePlus | |
| S595 | LKKTMsGTFLL | SH2 | PhosphoSitePlus |
| T294 | QDDPLtKGVDL | PhosphoSitePlus | |
| Dephosphorylation site |
| STAT2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000315768 | V286A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000315768 | E106K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000315768 | D746H | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000315768 | S506F | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| STAT2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| STAT2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JAK1_HUMAN | STAT2_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05168 | Herpes simplex infection |
| hsa04380 | Osteoclast differentiation |
| hsa04630 | Jak-STAT signaling pathway |
| hsa05160 | Hepatitis C |
| hsa04062 | Chemokine signaling pathway |
| hsa05162 | Measles |
| hsa05164 | Influenza A |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007259 | JAK-STAT cascade | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0060338 | regulation of type I interferon-mediated signaling | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |