Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STAT6_HUMAN
Description:signal transducer and activator of transcription 6, interleukin-4 induced [Source:HGNC Symbol;Acc:11368]
Location:chr12 q13.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y641KDGRGyVPATIJAK1RegPhos
T645GYVPAtIKMTVPhosphoSitePlus; phosphoELM; RegPhos
T525GVLDLtKRCLRSTAT_bindPhosphoSitePlus
S707PYQGLsPEESVPhosphoSitePlus
Y641KDGRGyVPATIPhosphoSitePlus; HPRD; RegPhos
S8LWGLVsKMPPEHPRD
S8LWGLVsKMPPESTAT_intPhosphoSitePlus
Y641KDGRGyVPATIJAK_groupphosphoELM; RegPhos
S756EHAVSsPDPLLPhosphoSitePlus; phosphoELM; RegPhos
S407QLQALsLPLVVSTAT_bindPhosphoSitePlus

Dephosphorylation site
STAT6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000451742D46NCOSMICOvarian Cancer21720365
ENSP00000401486D46NCOSMICOvarian Cancer21720365
ENSP00000401486V414LCOSMICOvarian Cancer21720365
ENSP00000438451D46NCOSMICOvarian Cancer21720365
ENSP00000438451Q71RCOSMICLung Cancer18948947
ENSP00000438451V414LCOSMICOvarian Cancer21720365
ENSP00000451742V414LCOSMICOvarian Cancer21720365
ENSP00000300134Q71RDing2008, COSMICLung Cancer18948947
ENSP00000451742Q71RCOSMICLung Cancer18948947
ENSP00000300134D46NCOSMICOvarian Cancer21720365
ENSP00000300134V414LCOSMICOvarian Cancer21720365
ENSP00000401486Q71RCOSMICLung Cancer18948947

Differential expressed protein
STAT6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
STAT6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSTAT6_HUMANkinase -> substrateRegPhos
AKT1_HUMANSTAT6_HUMANkinase -> substrateRobert H Newman (2013)
JAK1_HUMANSTAT6_HUMANkinase -> substrateRegPhos; NetPath
STAT6_HUMANOPRM_HUMANTF -> target geneTRANSFAC
STAT6_HUMANLOX15_HUMANTF -> target geneTRANSFAC
STAT6_HUMANIL4RA_HUMANTF -> target geneTRANSFAC
STAT6_HUMANIGHE_HUMANTF -> target geneTRANSFAC
STAT6_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STAT6_HUMANFCGR1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0033598mammary gland epithelial cell proliferationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0002829negative regulation of type 2 immune responseIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0002296T-helper 1 cell lineage commitmentIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0048295positive regulation of isotype switching to IgE isIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0060443mammary gland morphogenesisIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0000790nuclear chromatinIEAcellular_component
GO:0042127regulation of cell proliferationIEAbiological_process


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