Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGFR4_HUMAN
Description:fibroblast growth factor receptor 4 [Source:HGNC Symbol;Acc:3691]
Location:chr5 q35.2
Node attribute:substrate; kinase; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y642VHHIDyYKKTSPkinase_TyrPhosphoSitePlus
S440GVRLSsSGPALPhosphoSitePlus
S419LARQFsLESGSPhosphoSitePlus
S519LADLVsEMEVMPkinase_TyrPhosphoSitePlus
Y643HHIDYyKKTSNautocatalysis RegPhos
S441VRLSSsGPALLPhosphoSitePlus
Y643HHIDYyKKTSNPkinase_TyrPhosphoSitePlus
S533PGPDLsPDGPRHPRD
S573PGPDLsPDGPRPkinase_TyrPhosphoSitePlus
S439RGVRLsSSGPAPhosphoSitePlus
Y754AVSEEyLDLRLPhosphoSitePlus
S410TVQKLsRFPLAPhosphoSitePlus
Y754AVSEEyLDLRLFGFR4HPRD; phosphoELM; RegPhos
T167VPAGNtVKFRCI-setPhosphoSitePlus
S573PGPDLsPDGPRHPRD
Y714AVSEEyLDLRLFGFR4HPRD

Dephosphorylation site
FGFR4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000292410V510MGreenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000292410S732NGreenman2007Lung Cancer17344846, 18428421
ENSP00000292408D465NCOSMICGastric Cancer21097718
ENSP00000424960G397DTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000377254V510MGreenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000292410P672TGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000292408R616GDing2008Lung Cancer18948947
ENSP00000377254P672TGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000377254S732NGreenman2007Lung Cancer17344846, 18428421
ENSP00000292408R80WCOSMICProstate Cancer20668451
ENSP00000292408R183SDing2008Lung Cancer18948947
ENSP00000292408G397DTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000292408P712THPILung Cancer17344846
ENSP00000292408G397DCOSMICCentral Nervous System Neoplasms
ENSP00000292408R650HCOSMICOvarian Cancer21720365
ENSP00000292408D135NTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000292408E681KDing2008, COSMICLung Cancer18948947
ENSP00000424960D135NTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000292408G388ROMIMOther Cancer11830541
ENSP00000292408S232IDing2008Lung Cancer18948947
ENSP00000292408S772NHPILung Cancer17344846
ENSP00000292408A729GDing2008Lung Cancer18948947

Differential expressed protein
FGFR4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FGFR4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF23_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF5_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF4_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF19_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF8_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF1_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF2_HUMANFGFR4_HUMANligand -> receptorHPMR
FGFR4_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANNMI_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANCHSP1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANFGFR4_HUMANkinase -> substrateHPRD; RegPhos
FGFR4_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
FGFR4_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
FGFR4_HUMANRAP1A_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANCSN6_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANKC1G2_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANDCP1A_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANPHAX_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANARI3A_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANWT1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANHES1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
HNF1A_HUMANFGFR4_HUMANTF -> target geneTRANSFAC
SP1_HUMANFGFR4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04010MAPK signaling pathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0017134fibroblast growth factor bindingIPImolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaIPIbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0042593glucose homeostasisIEAbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:2000188regulation of cholesterol homeostasisIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0061144alveolar secondary septum developmentIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:2000573positive regulation of DNA biosynthetic processIMPbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005768endosomeIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0045862positive regulation of proteolysisIMPbiological_process
GO:0019216regulation of lipid metabolic processIEAbiological_process
GO:0010715regulation of extracellular matrix disassemblyIMPbiological_process
GO:0019216regulation of lipid metabolic processISSbiological_process
GO:0016477cell migrationIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005007fibroblast growth factor-activated receptor activiIEAmolecular_function
GO:0048554positive regulation of metalloenzyme activityIMPbiological_process
GO:0005911cell-cell junctionIDAcellular_component
GO:0070857regulation of bile acid biosynthetic processIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0055062phosphate ion homeostasisIEAbiological_process
GO:0001759organ inductionIEAbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component


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