Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGF2_HUMAN
Description:fibroblast growth factor 2 (basic) [Source:HGNC Symbol;Acc:3676]
Location:chr4 q27
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S250YNTYRsRKYTSFGFPhosphoSitePlus
S73ERGVVsIKGVCPKC_alphaphosphoELM
S138TMAAGsITTLPPhosphoSitePlus
S73ERGVVsIKGVCPKCa(PKC alphaRegPhos
S62SRAAGsPRTRGPhosphoSitePlus
Y245LESNNyNTYRSFGFPhosphoSitePlus
T254RSRKYtSWYVAFGFPhosphoSitePlus
T141AGSITtLPALPPhosphoSitePlus
T121RSRKYtSWYVAPKA_groupphosphoELM; RegPhos
S285LFLPMsAKS__PhosphoSitePlus
T65AGSPRtRGRRTPhosphoSitePlus
S206ERGVVsIKGVCFGFPhosphoSitePlus

Dephosphorylation site
FGF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264498H177NCOSMICLung Cancer20668451
ENSP00000264498I207VCOSMICCentral Nervous System Neoplasms18772396
ENSP00000264498S288RCOSMICOvarian Cancer21720365
ENSP00000264498S288RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
FGF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FGF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF2_HUMANFGFR3_HUMANligand -> receptorHPMR
FGF2_HUMANSDC4_HUMANligand -> receptorHPMR
FGF2_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF2_HUMANSDC2_HUMANligand -> receptorHPMR
FGF2_HUMANFGFR4_HUMANligand -> receptorHPMR
KPCA_HUMANFGF2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05218Melanoma
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0002042cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005125cytokine activityIDAmolecular_function
GO:0043536positive regulation of blood vessel endothelial ceIDAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0042056chemoattractant activityIDAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0061045negative regulation of wound healingIDAbiological_process
GO:0001759organ inductionIEAbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0021940positive regulation of cerebellar granule cell preIEAbiological_process
GO:0010863positive regulation of phospholipase C activityIDAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0060128corticotropin hormone secreting cell differentiatiIEAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaIPIbiological_process
GO:0050918positive chemotaxisIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0030214hyaluronan catabolic processIDAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005104fibroblast growth factor receptor bindingIEAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0005104fibroblast growth factor receptor bindingIPImolecular_function
GO:0006661phosphatidylinositol biosynthetic processIDAbiological_process
GO:0000189MAPK import into nucleusIEAbiological_process
GO:0048864stem cell developmentIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0042660positive regulation of cell fate specificationIDAbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0007165signal transductionNASbiological_process
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0010595positive regulation of endothelial cell migrationIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0008284positive regulation of cell proliferationIGIbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006700C21-steroid hormone biosynthetic processIEAbiological_process
GO:0060591chondroblast differentiationIDAbiological_process
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0042060wound healingTASbiological_process
GO:0045765regulation of angiogenesisTASbiological_process
GO:0046668regulation of retinal cell programmed cell deathIEAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0048598embryonic morphogenesisTASbiological_process
GO:0060644mammary gland epithelial cell differentiationIEAbiological_process
GO:0042060wound healingIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0043537negative regulation of blood vessel endothelial ceIDAbiological_process
GO:0021762substantia nigra developmentIEAbiological_process
GO:0010764negative regulation of fibroblast migrationIDAbiological_process
GO:0030374ligand-dependent nuclear receptor transcription coIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0043552positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0010001glial cell differentiationIEAbiological_process
GO:0017134fibroblast growth factor bindingIEAmolecular_function
GO:0008083growth factor activityIDAmolecular_function
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0048678response to axon injuryIEAbiological_process
GO:0060129thyroid-stimulating hormone-secreting cell differeIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0060548negative regulation of cell deathIDAbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0051209release of sequestered calcium ion into cytosolIDAbiological_process
GO:0032958inositol phosphate biosynthetic processIDAbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process