Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGF5_HUMAN
Description:fibroblast growth factor 5 [Source:HGNC Symbol;Acc:3683]
Location:chr4 q21.21
Node attribute:ligand

Phosphorylation site
FGF5_HUMAN do not have phosphorylation site.

Dephosphorylation site
FGF5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000311697S112FCOSMICBreast Cancer20668451
ENSP00000311697G71VCOSMICOvarian Cancer21720365
ENSP00000311697G132RCOSMICHead and Neck Cancer21798893
ENSP00000311697G71VTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000311697Breast CancerNormal vs. CancertissueDown0.9820857901
ENSP00000311697Breast CancerNormal vs. CancertissueDown0.3320857901
ENSP00000311697Breast CancerNormal vs. CancertissueUp320857901

Hyperphosphorylation site
FGF5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF5_HUMANFGFR4_HUMANligand -> receptorHPMR
FGF5_HUMANFGFR1_HUMANligand -> receptorHPMR
FGF5_HUMANFGFR2_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaIDAbiological_process
GO:0023019signal transduction involved in regulation of geneIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0005104fibroblast growth factor receptor bindingIDAmolecular_function
GO:0005615extracellular spaceTAScellular_component
GO:0008283cell proliferationTASbiological_process
GO:0010001glial cell differentiationIEAbiological_process
GO:0005576extracellular regionTAScellular_component


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