| UniProt/SwissProt ID: | FGF5_HUMAN |
| Description: | fibroblast growth factor 5 [Source:HGNC Symbol;Acc:3683] |
| Location: | chr4 q21.21 |
| Node attribute: | ligand |
| Phosphorylation site |
| FGF5_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| FGF5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000311697 | S112F | COSMIC | Breast Cancer | 20668451 | ENSP00000311697 | G71V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000311697 | G132R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000311697 | G71V | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000311697 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.98 | 20857901 | ENSP00000311697 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.33 | 20857901 | ENSP00000311697 | Breast Cancer | Normal vs. Cancer | tissue | Up | 3 | 20857901 |
| Hyperphosphorylation site |
| FGF5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FGF5_HUMAN | FGFR4_HUMAN | ligand -> receptor | HPMR |
| FGF5_HUMAN | FGFR1_HUMAN | ligand -> receptor | HPMR |
| FGF5_HUMAN | FGFR2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05200 | Pathways in cancer |
| hsa04010 | MAPK signaling pathway |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05218 | Melanoma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | IDA | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | IDA | biological_process |
| GO:0023019 | signal transduction involved in regulation of gene | IEA | biological_process |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0051781 | positive regulation of cell division | IEA | biological_process |
| GO:0005104 | fibroblast growth factor receptor binding | IDA | molecular_function |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0010001 | glial cell differentiation | IEA | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |