Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WT1_HUMAN
Description:Wilms tumor 1 [Source:HGNC Symbol;Acc:12796]
Location:chr11 p13
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S416CERRFsRSDQLPRKACAHPRD
S365CERRFsRSDQLPKA_groupphosphoELM; RegPhos
S365CERRFsRSDQLPKACaRegPhos
S393CQRKFsRSDHLPKA_groupphosphoELM; RegPhos
S393CQRKFsRSDHLOfd1_CTDD; zf-H2C2_2PhosphoSitePlus
S365CERRFsRSDQLOfd1_CTDD; zf-H2C2_2PhosphoSitePlus
S444CQRKFsRSDHLPRKACAHPRD
S393CQRKFsRSDHLPKACaRegPhos

Dephosphorylation site
WT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000435307T116IBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
WT1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANWT1_HUMANkinase -> substrateHPRD
FGFR4_HUMANWT1_HUMANkinase -> substrateRobert H Newman (2013)
GATA2_HUMANWT1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmIDAcellular_component
GO:0072207metanephric epithelium developmentIEPbiological_process
GO:0030539male genitalia developmentISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030855epithelial cell differentiationISSbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:2001076positive regulation of metanephric ureteric bud deISSbiological_process
GO:0007530sex determinationIEAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0005730nucleolusIEAcellular_component
GO:0072112glomerular visceral epithelial cell differentiatioISSbiological_process
GO:0001822kidney developmentIGIbiological_process
GO:0043010camera-type eye developmentIEAbiological_process
GO:0007281germ cell developmentIEAbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0061032visceral serous pericardium developmentIGIbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:0009888tissue developmentIEAbiological_process
GO:0016607nuclear speckIDAcellular_component
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0017148negative regulation of translationIDAbiological_process
GO:0072302negative regulation of metanephric glomerular mesaISSbiological_process
GO:0060923cardiac muscle cell fate commitmentISSbiological_process
GO:0001657ureteric bud developmentISSbiological_process
GO:0035802adrenal cortex formationISSbiological_process
GO:0060231mesenchymal to epithelial transitionISSbiological_process
GO:0003156regulation of organ formationISSbiological_process
GO:2000195negative regulation of female gonad developmentISSbiological_process
GO:0006357regulation of transcription from RNA polymerase IIISSbiological_process
GO:0072284metanephric S-shaped body morphogenesisIGIbiological_process
GO:0030325adrenal gland developmentIGIbiological_process
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0003700sequence-specific DNA binding transcription factorISSmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0032836glomerular basement membrane developmentIMPbiological_process
GO:0072166posterior mesonephric tubule developmentISSbiological_process
GO:0071371cellular response to gonadotropin stimulusIDAbiological_process
GO:0007356thorax and anterior abdomen determinationISSbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIGIbiological_process
GO:0071320cellular response to cAMPIEPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0001823mesonephros developmentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentISSbiological_process
GO:0060539diaphragm developmentISSbiological_process
GO:0060421positive regulation of heart growthISSbiological_process
GO:0007507heart developmentIGIbiological_process
GO:0008406gonad developmentISSbiological_process
GO:0072075metanephric mesenchyme developmentISSbiological_process
GO:0043066negative regulation of apoptotic processIGIbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0008380RNA splicingISSbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:2000020positive regulation of male gonad developmentISSbiological_process
GO:0001077RNA polymerase II core promoter proximal region seISSmolecular_function
GO:0001656metanephros developmentIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIGIbiological_process
GO:0032835glomerulus developmentIGIbiological_process