Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CBL_HUMAN
Description:Cbl proto-oncogene, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:1541]
Location:chr11 q23.3
Node attribute:substrate; ubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S833PRRINsERKAGPhosphoSitePlus
S639VPRLGsTFSLDPhosphoSitePlus
T568RPLPCtPGDCPPhosphoSitePlus
Y368VTQEQyELYCEPhosphoSitePlus; phosphoELM; RegPhos
Y774NEDDGyDVPKPYesphosphoELM
Y700EEDTEyMTPSSABL1RegPhos
S767TGPEEsENEDDPhosphoSitePlus
Y731IDSCTyEAMYNEGFRHPRD; RegPhos
S619LTNRHsLPFSLPRKCAHPRD
S794TLSDIsNASSSPhosphoSitePlus
Y731IDSCTyEAMYNHCKHPRD; RegPhos
S642LGSTFsLDTSMPRKCAHPRD
S520ALGTAsKAASGPhosphoSitePlus
Y731IDSCTyEAMYNSYKphosphoELM
Y774NEDDGyDVPKPSrcRegPhos
S589SRLGDsWLPRPPhosphoSitePlus
S791ARRTLsDISNAPhosphoSitePlus
S601PKVPVsAPSSSPhosphoSitePlus
Y731IDSCTyEAMYNSykRegPhos
Y735TYEAMyNIQSQPhosphoSitePlus
Y700EEDTEyMTPSSFynphosphoELM; RegPhos
Y371EQYELyCEMGSInsRRegPhos
Y774NEDDGyDVPKPInsRRegPhos
S716LDTSQsSRACDPhosphoSitePlus
S511RVCVPsSASALPhosphoSitePlus
Y700EEDTEyMTPSSINSRphosphoELM
T698EGEEDtEYMTPPhosphoSitePlus
Y370QEQYElYCEMGHPRD
S642LGSTFsLDTSMPhosphoSitePlus
S669IKPSSsANAIYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S646FSLDTsMSMNSPhosphoSitePlus
S623HSLPFsLPSQMPKCaRegPhos
S8GNVKKsSGAGGPhosphoSitePlus
Y552PPDRPySVGAEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y700EEDTEyMTPSSPhosphoSitePlus; phosphoELM; RegPhos
Y774NEDDGyDVPKPFynphosphoELM; RegPhos
Y141GKERMyEENSQCbl_NPhosphoSitePlus
S623HSLPFsLPSQMPhosphoSitePlus
Y700EEDTEyMTPSSEGFRHPRD; RegPhos
Y731IDSCTyEAMYNFynphosphoELM; RegPhos
Y731IDSCTyEAMYNFYNHPRD; RegPhos
S668KIKPSsSANAIPhosphoSitePlus; RegPhos
S514VPSSAsALGTAPhosphoSitePlus
S639VPRLGsTFSLDPRKCAHPRD
S439FDPRGsGSLLRPhosphoSitePlus
Y774NEDDGyDVPKPLckRegPhos
T702DTEYMtPSSRPPhosphoSitePlus
S717DTSQSsRACDCPhosphoSitePlus
Y731IDSCTyEAMYNSrcRegPhos
Y454GAPSPnYDDDDHPRD
Y551PPPDRpYSVGAHPRD
S512VCVPSsASALGPhosphoSitePlus
T126NLMKKtKQTISCbl_NPhosphoSitePlus
Y455APSPNyDDDDDPhosphoSitePlus; HPRD
Y700EEDTEyMTPSSYesphosphoELM; RegPhos
Y699GEEDTeYMTPSHPRD
S705YMTPSsRPLRPPhosphoSitePlus
S619LTNRHsLPFSLPhosphoSitePlus
Y674SANAIySLAARPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S642LGSTFsLDTSMPKCaRegPhos
T713LRPLDtSQSSRPhosphoSitePlus
S900FVSISsPAHVHPRD; phosphoELM; SysPTM
S20SGSGGsGSGGLPhosphoSitePlus
S799SNASSsFGWLSPhosphoSitePlus
Y371EQYELyCEMGSPhosphoSitePlus; phosphoELM
S441PRGSGsLLRQGPhosphoSitePlus
Y774NEDDGyDVPKPSykRegPhos
S623HSLPFsLPSQMPRKCAHPRD
Y371EQYELyCEMGSEGFRRegPhos
Y700EEDTEyMTPSSInsRRegPhos
S483VERPPsPFSMAPhosphoSitePlus; HPRD
Y371EQYELyCEMGSINSRHPRD; phosphoELM; RegPhos
S492MAPQAsLPPVPPhosphoSitePlus
Y774NEDDGyDVPKPABL1RegPhos
Y774NEDDGyDVPKPEGFRHPRD; RegPhos
S804SFGWLsLDGDPPhosphoSitePlus
T762AAHANtGPEESPhosphoSitePlus
Y700EEDTEyMTPSSLckRegPhos
S797DISNAsSSFGWPhosphoSitePlus
Y731IDSCTyEAMYNLckRegPhos
T640PRLGStFSLDTPhosphoSitePlus
S900FVSISsPAHVAPhosphoSitePlus; RegPhos; SysPTM
Y731IDSCTyEAMYNPhosphoSitePlus; HPRD; phosphoELM
Y731IDSCTyEAMYNYesphosphoELM; RegPhos
Y337FREGFyLFPDGphosphoELM; RegPhos
S452AEGAPsPNYDDPhosphoSitePlus; HPRD; phosphoELM
Y774NEDDGyDVPKPPhosphoSitePlus; phosphoELM; RegPhos
Y700EEDTEyMTPSSSykRegPhos
S639VPRLGsTFSLDPKCaRegPhos
S704EYMTPsSRPLRPhosphoSitePlus
Y700EEDTEyMTPSSSYKphosphoELM
S619LTNRHsLPFSLPKCaRegPhos
Y774NEDDGyDVPKPSYKphosphoELM
S675ANAIYsLAARPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T789VLARRtLSDISPhosphoSitePlus
S667PKIKPsSSANAPhosphoSitePlus; HPRD; phosphoELM; RegPhos

Dephosphorylation site
CBL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264033Y368*COSMICLymphoma20678218
ENSP00000264033Q367RCOSMICLymphoma20644105
ENSP00000264033K382EHPILeukemia20619386
ENSP00000264033E366KCOSMICLymphoma20678218
ENSP00000264033W609*COSMICCentral Nervous System Neoplasms18772890
ENSP00000264033W802*COSMICLung Cancer20126411
ENSP00000264033L399VCOSMICLymphoma22131879
ENSP00000264033Q249ECOSMICLung Cancer20126411
ENSP00000264033C401YCOSMICLymphoma20644105
ENSP00000264033Q367PHPILeukemia20619386
ENSP00000264033D390GCOSMICLymphoma21988239
ENSP00000264033I292VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000264033S376FCOSMICLymphoma19387008
ENSP00000264033P428LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000264033C419RCOSMICLymphoma20357823
ENSP00000264033C416WCOSMICLymphoma22131879
ENSP00000264033A848TCOSMICLung Cancer20126411
ENSP00000264033H320DCOSMICLung Cancer20668451
ENSP00000264033P395ACOSMICLymphoma21346257
ENSP00000264033G415SCOSMICLymphoma22131879
ENSP00000264033Y371HOMIMLeukemia20543203 19571318 20694012
ENSP00000264033N454DCOSMICLymphoma19387008
ENSP00000264033S80NCOSMICLung Cancer20126411
ENSP00000264033P428LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000264033P417LCOSMICLymphoma20678218
ENSP00000264033C381RCOSMICLymphoma20678218
ENSP00000264033G375SCOSMICLymphoma17475912
ENSP00000264033C404YCOSMICLymphoma20644105
ENSP00000264033R830KCOSMICLung Cancer20126411
ENSP00000264033H398RCOSMICLymphoma20644105
ENSP00000264033K382ECOSMICLymphoma20674974
ENSP00000264033M374VCOSMICLymphoma21988239
ENSP00000264033R420QHPILeukemia20619386 22246246
ENSP00000264033D390YHPILeukemia20619386
ENSP00000264033R462*COSMICLymphoma19387008
ENSP00000264033M400RCOSMICLymphoma20644105
ENSP00000264033H94YCOSMICLung Cancer20126411
ENSP00000264033C396RCOSMICLymphoma20644105
ENSP00000264033K287RCOSMICLymphoma20622007
ENSP00000264033L380PCOSMICLymphoma20678218
ENSP00000264033R420QCOSMICLymphoma20644105
ENSP00000264033W609*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000264033R499LCOSMICLymphoma20622007
ENSP00000264033C384RCOSMICLymphoma20644105
ENSP00000264033W408LCOSMICLymphoma21909114
ENSP00000264033Y371SCOSMICLymphoma22131879
ENSP00000264033V391ICOSMICLung Cancer20126411
ENSP00000264033F418SCOSMICLymphoma22131879

Differential expressed protein
CBL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CBL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FASTK_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCBL_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
CDK15_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
PRKY_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KC1G2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
NRBP2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
PAK4_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
ABL1_HUMANCBL_HUMANkinase -> substrateRegPhos
ABL2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANCBL_HUMANkinase -> substrateRegPhos
FYN_HUMANCBL_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
STK16_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
INSR_HUMANCBL_HUMANkinase -> substrateHPRD; RegPhos
PAK6_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANCBL_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
WEE1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
MAK_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KC1G3_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANCBL_HUMANkinase -> substrateRegPhos
TNI3K_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
PACE1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
DDR2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
HCK_HUMANCBL_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ARAF_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
SIK1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
MK15_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
CBL_HUMANLYN_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04120Ubiquitin mediated proteolysis
hsa05100Bacterial invasion of epithelial cells
hsa05220Chronic myeloid leukemia
hsa04630Jak-STAT signaling pathway
hsa04910Insulin signaling pathway
hsa04660T cell receptor signaling pathway
hsa04012ErbB signaling pathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0046875ephrin receptor bindingIPImolecular_function
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0004842ubiquitin-protein ligase activityTASmolecular_function
GO:0017124SH3 domain bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0016600flotillin complexISScellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0048260positive regulation of receptor-mediated endocytosTASbiological_process
GO:0016567protein ubiquitinationTASbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0001784phosphotyrosine bindingIEAmolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016600flotillin complexIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0004871signal transducer activityIEAmolecular_function