| UniProt/SwissProt ID: | FRK_HUMAN |
| Description: | fyn-related kinase [Source:HGNC Symbol;Acc:3955] |
| Location: | chr6 q22.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y387 | DNEDIyESRHE | Pkinase_Tyr | PhosphoSitePlus; SysPTM |
| S102 | QGYIPsNYVAE | SH3_1 | PhosphoSitePlus |
| Y387 | DNEDIyESRHE | HPRD; phosphoELM; SysPTM | |
| S93 | RRDGSsQQLQG | SH3_1 | PhosphoSitePlus |
| Y368 | GEHNIyKVADF | Pkinase_Tyr | PhosphoSitePlus |
| Y497 | ETDSSySDANN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y193 | EFVSHyTKTSD | SH2 | PhosphoSitePlus |
| S62 | TAEDLsFRAGD | HPRD; SysPTM | |
| Y132 | EKQLLySENKT | SH2 | PhosphoSitePlus |
| S133 | KQLLYsENKTG | SH2 | PhosphoSitePlus |
| Y303 | LEDPIyIITEL | Pkinase_Tyr | PhosphoSitePlus |
| Y104 | YIPSNyVAEDR | PhosphoSitePlus | |
| S184 | RRRIFsTLNEF | SH2 | PhosphoSitePlus |
| S62 | TAEDLsFRAGD | SH3_1 | PhosphoSitePlus; SysPTM |
| S145 | FLIREsESQKG | SH2 | PhosphoSitePlus |
| Y53 | VALFDyQARTA | SH3_1 | PhosphoSitePlus |
| Y221 | PFDLSyKTVDQ | PhosphoSitePlus | |
| S92 | KRRDGsSQQLQ | SH3_1 | PhosphoSitePlus |
| S37 | PGALCsPQSQR | PhosphoSitePlus; HPRD; SysPTM | |
| S389 | EDIYEsRHEIK | Pkinase_Tyr | PhosphoSitePlus |
| S496 | FETDSsYSDAN | PhosphoSitePlus | |
| S147 | IRESEsQKGEF | SH2 | PhosphoSitePlus |
| S139 | ENKTGsFLIRE | SH2 | PhosphoSitePlus |
| Y46 | QRHGHyFVALF | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S498 | TDSSYsDANNF | PhosphoSitePlus | |
| Y317 | GSLQEyLQNDT | Pkinase_Tyr | PhosphoSitePlus |
| S495 | YFETDsSYSDA | PhosphoSitePlus | |
| Y99 | QQLQGyIPSNY | SH3_1 | PhosphoSitePlus |
| Dephosphorylation site |
| FRK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357615 | R406H | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000357615 | Y193* | Greenman2007 | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| FRK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y387 | Pkinase_Tyr | KVDNEDIyESRHEIK | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FRK_HUMAN | PP1R8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | CUED2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | SIN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | MYEF2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | RUVB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | RBM27_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | THOC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | HM20B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | FRK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | GTF2I_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FRK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005622 | intracellular | TAS | cellular_component |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |