Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FRK_HUMAN
Description:fyn-related kinase [Source:HGNC Symbol;Acc:3955]
Location:chr6 q22.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y387DNEDIyESRHEPkinase_TyrPhosphoSitePlus; SysPTM
S102QGYIPsNYVAESH3_1PhosphoSitePlus
Y387DNEDIyESRHEHPRD; phosphoELM; SysPTM
S93RRDGSsQQLQGSH3_1PhosphoSitePlus
Y368GEHNIyKVADFPkinase_TyrPhosphoSitePlus
Y497ETDSSySDANNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y193EFVSHyTKTSDSH2PhosphoSitePlus
S62TAEDLsFRAGDHPRD; SysPTM
Y132EKQLLySENKTSH2PhosphoSitePlus
S133KQLLYsENKTGSH2PhosphoSitePlus
Y303LEDPIyIITELPkinase_TyrPhosphoSitePlus
Y104YIPSNyVAEDRPhosphoSitePlus
S184RRRIFsTLNEFSH2PhosphoSitePlus
S62TAEDLsFRAGDSH3_1PhosphoSitePlus; SysPTM
S145FLIREsESQKGSH2PhosphoSitePlus
Y53VALFDyQARTASH3_1PhosphoSitePlus
Y221PFDLSyKTVDQPhosphoSitePlus
S92KRRDGsSQQLQSH3_1PhosphoSitePlus
S37PGALCsPQSQRPhosphoSitePlus; HPRD; SysPTM
S389EDIYEsRHEIKPkinase_TyrPhosphoSitePlus
S496FETDSsYSDANPhosphoSitePlus
S147IRESEsQKGEFSH2PhosphoSitePlus
S139ENKTGsFLIRESH2PhosphoSitePlus
Y46QRHGHyFVALFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S498TDSSYsDANNFPhosphoSitePlus
Y317GSLQEyLQNDTPkinase_TyrPhosphoSitePlus
S495YFETDsSYSDAPhosphoSitePlus
Y99QQLQGyIPSNYSH3_1PhosphoSitePlus

Dephosphorylation site
FRK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357615R406HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000357615Y193*Greenman2007Lung Cancer16140923, 17344846, 18428421

Differential expressed protein
FRK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y387Pkinase_TyrKVDNEDIyESRHEIKcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
FRK_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANCUED2_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANSIN1_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANMYEF2_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANDDX25_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANRBM27_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANTHOC1_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANHM20B_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
STYK1_HUMANFRK_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
FRK_HUMANGTF2I_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
FRK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005622intracellularTAScellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function


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