Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ATM_HUMAN
Description:ataxia telangiectasia mutated [Source:HGNC Symbol;Acc:795]
Location:chr11 q22.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1981AFEEGsQSTTIphosphoELM; RegPhos; SysPTM
S440LLMILsQLLPQATMHPRD; RegPhos
S367RSLEIsQSYTTATMHPRD; RegPhos
S2996CKRNLsDIDQSHPRD
S1104DTKGDsSRLLKHPRD
T373QSYTTtQRESSHPRD; phosphoELM; RegPhos
S367RSLEIsQSYTTphosphoELM; RegPhos
T72YIQKEtECLRIHPRD; phosphoELM; RegPhos
S1981AFEEGsQSTTIATMHPRD; phosphoELM; RegPhos; SysPTM
S1655NLLQLsKMAINHPRD
S1981AFEEGsQSTTIautocatalysisRegPhos; SysPTM
S1893NLDSEsEHFFRATMHPRD; RegPhos
S85PNVSAsTQASRHPRD; phosphoELM; RegPhos
S809LRLLTsKLMNDHPRD
S1987QSTTIsSLSEKATMHPRD
T86NVSAStQASRQHPRD; phosphoELM; RegPhos; SysPTM
T1985GSQSTtISSLSHPRD; phosphoELM; RegPhos
S800PNKIAsGFFLRHPRD
S1993SLSEKsKEETGHPRD
T1662MAINHtGEKEVHPRD
S1987QSTTIsSLSEKphosphoELM; RegPhos

Dephosphorylation site
ATM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000278616E1991DGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000278616S2408LGreenman2007Intestines Cancer17344846, 18428421
ENSP00000278616R1086LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616L1718VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000278616T2666AGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000278616L2417PDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616S853*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616D1682HOMIM, HPILeukemia9288106
ENSP00000278616V2424GOMIMLeukemia9288106 9463314 16958054
ENSP00000278616N1739TGreenman2007Intestines Cancer17344846, 18428421
ENSP00000278616L1322PDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616V2424GHPIchronic lymphocytic leukemia8755918 9288106 9463314 9892178 17001622
ENSP00000278616G558*Greenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000278616F1463SHPILymphoma9288106
ENSP00000278616S49COMIMBreast Cancer16652348 12362033 15042666
ENSP00000278616V245ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000278616H2872QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616Y332CHPIchronic lymphocytic leukemia9892178
ENSP00000278616E1267KBIOMARTBreast Cancer21930507, 21930502
ENSP00000278616A1945THPIColorectal Cancer17344846
ENSP00000278616M1040VOMIM, HPILymphoma9288106
ENSP00000278616R2443QHPIColorectal Cancer17344846
ENSP00000278616A350THPIchronic lymphocytic leukemia10023947
ENSP00000278616K3018NHPIchronic lymphocytic leukemia10397742
ENSP00000278616A1945TGreenman2007Intestines Cancer17344846, 18428421
ENSP00000278616R2453PDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616R337HGreenman2007Intestines Cancer17344846, 18428421
ENSP00000278616L2890VHPILeukemia9288106 9488043
ENSP00000278616Y1915*BIOMARTBrain Cancer21930507, 21930502
ENSP00000388058V245ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000278616R2443QGreenman2007Neoplasms by Histologic Type16461462, 17344846, 18428421
ENSP00000278616V2424GOMIMBreast Cancer9288106 9463314 16958054
ENSP00000278616I2888TBIOMARTBreast Cancer21930507, 21930502
ENSP00000278616E2423GOMIM, HPILymphoma10706620, 10397742 10706620
ENSP00000278616T2396SHPILeukemia9288106
ENSP00000278616D2708NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000388058R2912KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000278616I1407THPILeukemia9288106
ENSP00000278616N1739THPIColorectal Cancer17344846
ENSP00000278616C540YHPIColorectal Cancer17344846
ENSP00000278616G138RTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000278616C540YGreenman2007Intestines Cancer17344846, 18428421
ENSP00000278616D2725VHPILeukemia9288106
ENSP00000278616R23QHPIColorectal Cancer17344846
ENSP00000278616A2274THPIchronic lymphocytic leukemia10023947
ENSP00000388058D2507NTCGAOvarian Cancer21720365, 18772890
ENSP00000278616F2732LHPILeukemia9288106
ENSP00000278616M1916IGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421
ENSP00000278616E2139GHPILeukemia9488043
ENSP00000278616R2443QGreenman2007Intestines Cancer16461462, 17344846, 18428421
ENSP00000278616R3008HHPIchronic lymphocytic leukemia10397742
ENSP00000388058G138RTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000278616L2033VBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000278616V2951FBIOMARTBrain Cancer21930507, 21930502
ENSP00000388058E1267KBIOMARTBreast Cancer21930507, 21930502
ENSP00000388058L1718VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000278616S1179FGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000278616R337CGreenman2007Intestines Cancer17344846, 18428421
ENSP00000278616I2356FGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000278616D1208HTCGAOvarian Cancer21720365, 18772890
ENSP00000278616Y2954CTCGAOvarian Cancer21720365, 18772890
ENSP00000278616E848QGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000388058I2888TBIOMARTBreast Cancer21930507, 21930502
ENSP00000278616S1691RHPIchronic lymphocytic leukemia8797579 9463314 9892178
ENSP00000278616G2695AHPILeukemia9288106 10023947
ENSP00000278616A3006PHPILeukemia9334731
ENSP00000278616R23QGreenman2007Intestines Cancer17344846, 18428421
ENSP00000278616E2164KHPILeukemia9288106
ENSP00000278616Q747HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616I1469MGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000278616E2052*Greenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000278616Q2442PDing2008, HPI, Greenman2007Leukemia16140923, 17344846, 18428421, 18948947, 9288106, 21930507, 21930502, 9288106, 17344846, 9288106 17344846
ENSP00000278616R337HHPIColorectal Cancer17344846
ENSP00000278616L2722RHPILeukemia9288106
ENSP00000278616Q2442PDing2008, Greenman2007Neoplasms by Histologic Type16140923, 17344846, 18428421, 18948947, 9288106
ENSP00000278616S2375IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616S2408LHPIColorectal Cancer17344846
ENSP00000278616D2507NTCGAOvarian Cancer21720365, 18772890
ENSP00000388058Y2954CTCGAOvarian Cancer21720365, 18772890
ENSP00000278616P2842RGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000278616I352THPIchronic lymphocytic leukemia10023947
ENSP00000278616Q2442PDing2008, BIOMART, Greenman2007Lung Cancer16140923, 17344846, 18428421, 18948947, 9288106, 21930507, 21930502, 9288106, 17344846
ENSP00000278616T1953RHPIchronic lymphocytic leukemia10397742
ENSP00000278616R2912KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000278616R2486GHPILeukemia9573030
ENSP00000278616S1905LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000278616L1910HHPILeukemia9288106
ENSP00000278616A2420PHPIchronic lymphocytic leukemia10397742
ENSP00000388058D1208HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000278616Breast CancerNormal vs. CancertissueUp2.116470630

Hyperphosphorylation site
ATM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATM_HUMANRAD17_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANATM_HUMANkinase -> substrateRegPhos
ATM_HUMANTOPB1_HUMANkinase -> substrateRegPhos
ATM_HUMANMRE11_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMAN4EBP1_HUMANkinase -> substrateRegPhos
ATM_HUMANSTK11_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMANTP53B_HUMANkinase -> substrateRegPhos
ATM_HUMANMCM3_HUMANkinase -> substrateRegPhos
ATM_HUMANBLM_HUMANkinase -> substrateRegPhos
ATM_HUMANATF2_HUMANkinase -> substrateRegPhos
ATM_HUMANNEMO_HUMANkinase -> substrateRegPhos
ATM_HUMANCHK1_HUMANkinase -> substrateRegPhos
ATM_HUMANATM_HUMANkinase -> substrateRegPhos
ATM_HUMANNBN_HUMANkinase -> substrateRegPhos
ATM_HUMANXPA_HUMANkinase -> substrateRegPhos
ATM_HUMANRFA2_HUMANkinase -> substrateRegPhos
ATM_HUMANCOM1_HUMANkinase -> substrateRegPhos
ATM_HUMANBRCA1_HUMANkinase -> substrateRegPhos
ATM_HUMANABL1_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMANCREB1_HUMANkinase -> substrateRegPhos
ATM_HUMANFACD2_HUMANkinase -> substrateRegPhos
ATM_HUMANNFAT5_HUMANkinase -> substrateRegPhos
ATM_HUMANSMC1A_HUMANkinase -> substrateRegPhos
ATM_HUMANDNLI4_HUMANkinase -> substrateRegPhos
ATM_HUMANDCR1C_HUMANkinase -> substrateRegPhos
ATM_HUMANE2F1_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMANTBL2_HUMANkinase -> substrateRegPhos
ATM_HUMANCHK2_HUMANkinase -> substrateRegPhos
ATM_HUMANMDM4_HUMANkinase -> substrateHPRD
ATM_HUMANH2AX_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMANTERF1_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMANP53_HUMANkinase -> substrateRegPhos
ATM_HUMANRAD9A_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMANRAD50_HUMANkinase -> substrateRegPhos
ATM_HUMANMDM2_HUMANkinase -> substrateRegPhos
ATM_HUMANWRN_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa04064NF-kappa B signaling pathway
hsa05166HTLV-I infection
hsa04210Apoptosis
hsa04110Cell cycle
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008630intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0030889negative regulation of B cell proliferationIMPbiological_process
GO:0071044histone mRNA catabolic processIDAbiological_process
GO:0007131reciprocal meiotic recombinationTASbiological_process
GO:0006975DNA damage induced protein phosphorylationIDAbiological_process
GO:0051402neuron apoptotic processIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0002331pre-B cell allelic exclusionIEAbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0006302double-strand break repairTASbiological_process
GO:0046983protein dimerization activityIDAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0007094mitotic cell cycle spindle assembly checkpointIMPbiological_process
GO:0000077DNA damage checkpointIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0035404histone-serine phosphorylationIEAbiological_process
GO:0000781chromosome, telomeric regionIDAcellular_component
GO:0000724double-strand break repair via homologous recombinTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0042159lipoprotein catabolic processIEAbiological_process
GO:0000723telomere maintenanceIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0036092phosphatidylinositol-3-phosphate biosynthetic procIMPbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0010212response to ionizing radiationIEAbiological_process
GO:00163031-phosphatidylinositol-3-kinase activityIMPmolecular_function
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007050cell cycle arrestIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005819spindleIEAcellular_component
GO:0051726regulation of cell cycleIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0004677DNA-dependent protein kinase activityIDAmolecular_function
GO:0043517positive regulation of DNA damage response, signalIMPbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0090399replicative senescenceIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process
GO:0032403protein complex bindingIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0035174histone serine kinase activityIEAmolecular_function
GO:0016572histone phosphorylationIEAbiological_process
GO:0031572G2/M transition DNA damage checkpointIMPbiological_process
GO:0007292female gamete generationIEAbiological_process
GO:0071480cellular response to gamma radiationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0047485protein N-terminus bindingIDAmolecular_function
GO:0006915apoptotic processIEAbiological_process