| UniProt/SwissProt ID: | TOPB1_HUMAN |
| Description: | topoisomerase (DNA) II binding protein 1 [Source:HGNC Symbol;Acc:17008] |
| Location: | chr3 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1002 | MSLDIsAVQDG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S554 | EEGLFsQKSFL | BRCT | PhosphoSitePlus |
| T742 | LIENStKEERS | PhosphoSitePlus | |
| T1221 | SEELEtPIKDS | PhosphoSitePlus; HPRD | |
| S498 | QYENGsSTVVE | PhosphoSitePlus | |
| T848 | LAALEtPGRPS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S853 | TPGRPsQQKRK | ATM | HPRD; RegPhos |
| S805 | RQVAAsPAVGQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S1138 | VNTEPsQNEQI | PhosphoSitePlus; phosphoELM; RegPhos | |
| S1138 | VNTEPsQNEQI | ATM | HPRD; RegPhos |
| S350 | ENLDVsAFQAP | PhosphoSitePlus; HPRD | |
| S860 | QKRKPsTPLSE | PhosphoSitePlus; HPRD; phosphoELM | |
| S492 | DEDLLsQYENG | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y127 | EEVHKyVQMMG | BRCT | PhosphoSitePlus |
| T1062 | SKGVLtQTLEM | ATM | HPRD; RegPhos |
| T1062 | SKGVLtQTLEM | PhosphoSitePlus; phosphoELM; RegPhos | |
| S554 | EEGLFsQKSFL | ATM | HPRD; RegPhos |
| T144 | LNVSVtHLIAG | HPRD | |
| S888 | VALSAsPQLKE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S301 | SSTPTsQINTI | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S587 | IMSLLsRTVAD | BRCT | PhosphoSitePlus |
| T779 | RKTVVtPLDMN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S1093 | QGQRTsLSRSG | PhosphoSitePlus | |
| S1504 | LGTGLsQKRKA | PhosphoSitePlus | |
| S1012 | GRLCNsRLLSA | PhosphoSitePlus; HPRD; SysPTM | |
| S886 | NAVALsASPQL | PhosphoSitePlus; HPRD | |
| S153 | AGEVGsKKYLV | BRCT | PhosphoSitePlus |
| S492 | DEDLLsQYENG | ATM | HPRD; RegPhos |
| S1159 | RARLAsNLQWP | PhosphoSitePlus | |
| S142 | RDLNVsVTHLI | BRCT | PhosphoSitePlus |
| S499 | YENGSsTVVEA | PhosphoSitePlus | |
| T298 | MPNSStPTSQI | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S142 | RDLNVsVTHLI | HPRD | |
| T861 | KRKPStPLSEV | PhosphoSitePlus; HPRD; phosphoELM | |
| S864 | PSTPLsEVIVK | PhosphoSitePlus; HPRD; phosphoELM | |
| T300 | NSSTPtSQINT | PhosphoSitePlus | |
| T618 | NTWLVtCIDYQ | BRCT | PhosphoSitePlus |
| S741 | FLIENsTKEER | PhosphoSitePlus | |
| S853 | TPGRPsQQKRK | PhosphoSitePlus | |
| Dephosphorylation site |
| TOPB1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000260810 | S471N | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TOPB1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TOPB1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ATM_HUMAN | TOPB1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | TOPB1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| TOPB1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006281 | DNA repair | NAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0005694 | chromosome | IEA | cellular_component |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0010212 | response to ionizing radiation | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000922 | spindle pole | IEA | cellular_component |
| GO:0001673 | male germ cell nucleus | IEA | cellular_component |
| GO:0005815 | microtubule organizing center | IEA | cellular_component |
| GO:0000794 | condensed nuclear chromosome | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0005694 | chromosome | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0008022 | protein C-terminus binding | TAS | molecular_function |