Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEMO_HUMAN
Description:inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Source:HGNC Symbol;Acc:5961]
Location:chrX q28
Node attribute:substrate; kinase; ubiquitination(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S376APAYLsSPLALIKBKBHPRD
S43MLHLPsEQGAPIKK_betaphosphoELM
S31VLGEEsPLGKPPhosphoSitePlus
S376APAYLsSPLALIKK_betaphosphoELM
S43MLHLPsEQGAPIKKbRegPhos
S376APAYLsSPLALIKKb(IKK betaRegPhos
S31VLGEEsPLGKPIKKbRegPhos
S31VLGEEsPLGKPIKBKBHPRD
S376APAYLsSPLALPhosphoSitePlus
S377PAYLSsPLALPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S376APAYLsSPLALIKKbRegPhos
S31VLGEEsPLGKPIKKb(IKK betaRegPhos
Y308AQADIyKADFQPhosphoSitePlus
S387PSQRRsPPEEPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S43MLHLPsEQGAPPhosphoSitePlus
S31VLGEEsPLGKPIKK_betaphosphoELM
Y374PPAPAyLSSPLPhosphoSitePlus
S85LHFQAsQREEKATMphosphoELM; RegPhos
S178RARAAsEQARQBacillus_HBLPhosphoSitePlus
S43MLHLPsEQGAPIKBKBHPRD
S383PLALPsQRRSPPhosphoSitePlus; HPRD
S85LHFQAsQREEKNEMOPhosphoSitePlus
S68DAIRQsNQILRNEMOPhosphoSitePlus
T297KIVMEtVPVLKPhosphoSitePlus; HPRD
S43MLHLPsEQGAPIKKb(IKK betaRegPhos

Dephosphorylation site
NEMO_HUMAN do not have dephosphorylation site.

Mutation site
NEMO_HUMAN do not have mutation site.

Differential expressed protein
NEMO_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NEMO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATM_HUMANNEMO_HUMANkinase -> substrateRegPhos
IKKB_HUMANNEMO_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
NEMO_HUMANIKBA_HUMANkinase -> substrateHPRD
BIRC2_HUMANNEMO_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa05168Herpes simplex infection
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05203Viral carcinogenesis
hsa04622RIG-I-like receptor signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04062Chemokine signaling pathway
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05166HTLV-I infection
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa05131Shigellosis
hsa05221Acute myeloid leukemia
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05340Primary immunodeficiency
hsa04064NF-kappa B signaling pathway
hsa05169Epstein-Barr virus infection
hsa04920Adipocytokine signaling pathway
hsa04662B cell receptor signaling pathway
hsa05215Prostate cancer
hsa05120Epithelial cell signaling in Helicobacter pylori i

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0019904protein domain specific bindingIPImolecular_function
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0009615response to virusTASbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0005622intracellularIDAcellular_component
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0006955immune responseTASbiological_process
GO:0050852T cell receptor signaling pathwayNASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0044444cytoplasmic partIDAcellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0007250activation of NF-kappaB-inducing kinase activityIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0008385IkappaB kinase complexTAScellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001782B cell homeostasisIEAbiological_process


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