Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MCM3_HUMAN
Description:minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:6945]
Location:chr6 p12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S160IERRYsDLTTLDAPK1phosphoELM
Y705KDGDSyDPYDFPhosphoSitePlus; phosphoELM
S711DPYDFsDTEEEPhosphoSitePlus; phosphoELM; RegPhos
S599YSRLRsQDSMSMCMPhosphoSitePlus
T617PVTARtLETLIMCMPhosphoSitePlus
T240VQVVGtYRCLPPhosphoSitePlus
T555NLLHGtKKKKEMCMPhosphoSitePlus
T722MPQVHtPKTADPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
T252KKGGYtSGTFRPhosphoSitePlus
S734QETKEsQKVELPhosphoSitePlus; phosphoELM; RegPhos
T713YDFSDtEEEMPPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S668KRKKRsEDESEPhosphoSitePlus; phosphoELM; RegPhos
Y19EAQRDyLDFLDPhosphoSitePlus
S170LVAFPsSSVYPPhosphoSitePlus
S171VAFPSsSVYPTPhosphoSitePlus
T255GYTSGtFRTVLPhosphoSitePlus
T164YSDLTtLVAFPPhosphoSitePlus
S681DEEEKsQEDQEPhosphoSitePlus; phosphoELM; RegPhos
Y708DSYDPyDFSDTPhosphoSitePlus; phosphoELM; RegPhos
T163RYSDLtTLVAFPhosphoSitePlus
Y159TIERRySDLTTPhosphoSitePlus
Y545QDTQIyEKHDNMCMPhosphoSitePlus
S672RSEDEsETEDEPhosphoSitePlus; phosphoELM; RegPhos
T176SSVYPtKDEENPhosphoSitePlus
S704AKDGDsYDPYDPhosphoSitePlus; phosphoELM; RegPhos
S535DDPNFsQEDQQMCMPhosphoSitePlus
S728PKTADsQETKEPhosphoSitePlus; phosphoELM; RegPhos
S535DDPNFsQEDQQATMRegPhos
S112GSKHVsPRTLTPhosphoSitePlus
Y32EDQGIyQSKVRPhosphoSitePlus
T725VHTPKtADSQEPhosphoSitePlus
T4__MAGtVVLDDPhosphoSitePlus
S160IERRYsDLTTLPhosphoSitePlus; phosphoELM
T674EDESEtEDEEEPhosphoSitePlus; phosphoELM; RegPhos
Y651VELVQyAYFKKMCMPhosphoSitePlus

Dephosphorylation site
MCM3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000229854V425MCOSMICMelanoma
ENSP00000229854R138LCOSMICHead and Neck Cancer21798893
ENSP00000229854A509VCOSMICOvarian Cancer21720365
ENSP00000229854V137FCOSMICHead and Neck Cancer21798893
ENSP00000229854Q353KCOSMICHead and Neck Cancer21798893

Differential expressed protein
MCM3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MCM3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATM_HUMANMCM3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMCM3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03030DNA replication
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0042555MCM complexIDAcellular_component
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0015979photosynthesisIEAbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0006270DNA replication initiationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0004386helicase activityIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0016851magnesium chelatase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005658alpha DNA polymerase:primase complexTAScellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0015995chlorophyll biosynthetic processIEAbiological_process
GO:0006260DNA replicationTASbiological_process


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