Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DCR1C_HUMAN
Description:DNA cross-link repair 1C [Source:HGNC Symbol;Acc:17642]
Location:chr10 p13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S525KLFSDsDGESTATMRegPhos
S423SSQNSsQSTHIATMHPRD
T613RDKDVtIVPSTPhosphoSitePlus
S419STHISsQNSSQATMHPRD
S442TVLLSsQERNSATMHPRD
S447TVLLSsQERNSATMHPRD
S548ITEQGsQGWDSPhosphoSitePlus
T136TTDRNtQIHACATMHPRD
S433SQGWDsQSDTVATMHPRD
S438SQGWDsQSDTVATMHPRD
S525STNADsQSSSDATMHPRD
S645STNADsQSSSDATMHPRD; RegPhos
S626PTTLSsETHIPPhosphoSitePlus
S538SSQNSsQSTHIPhosphoSitePlus
S625EPTTLsSETHIPhosphoSitePlus
S553SQGWDsQSDTVPhosphoSitePlus
S401TVAGGsQSPKLATMHPRD
S516TVAGGsQSPKLPhosphoSitePlus
S534STHISsQNSSQPhosphoSitePlus
T380LKRARtVHRDSPhosphoSitePlus
S503EITDEsLENFPPhosphoSitePlus
S414STHISsQNSSQATMHPRD
T251TTDRNtQIHACATMHPRD; RegPhos
S688KKRKCsLLDT_PhosphoSitePlus
T91EIETPtQISLVATMHPRD; RegPhos
S534STHISsQNSSQATMHPRD; RegPhos
S538SSQNSsQSTHIATMHPRD; RegPhos
T131TTDRNtQIHACATMHPRD
S516TVAGGsQSPKLATMHPRD; RegPhos
S562TVLLSsQERNSATMHPRD; RegPhos
S530STNADsQSSSDATMHPRD
Y264PKAEEyFQWSKDRMBLPhosphoSitePlus
T676YEKLAtGESIAPhosphoSitePlus
S553SQGWDsQSDTVATMHPRD; RegPhos
S645STNADsQSSSDPhosphoSitePlus
S418SSQNSsQSTHIATMHPRD
S396TVAGGsQSPKLATMHPRD
S607YSDLKsRDKDVPhosphoSitePlus

Dephosphorylation site
DCR1C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367496T102NCOSMICOvarian Cancer21720365
ENSP00000367492T102NCOSMICOvarian Cancer21720365
ENSP00000367527T217NCOSMICOvarian Cancer21720365
ENSP00000350349T102NCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000367527Breast CancerMetastasistissueUp18257521

Hyperphosphorylation site
DCR1C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATM_HUMANDCR1C_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05340Primary immunodeficiency
hsa03450Non-homologous end-joining

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006310DNA recombinationIEAbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0000014single-stranded DNA specific endodeoxyribonucleaseIDAmolecular_function
GO:0030183B cell differentiationIEAbiological_process
GO:00084095'-3' exonuclease activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0051276chromosome organizationIEAbiological_process
GO:0000723telomere maintenanceIEAbiological_process
GO:0010212response to ionizing radiationIEAbiological_process


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