| UniProt/SwissProt ID: | FACD2_HUMAN |
| Description: | Fanconi anemia, complementation group D2 [Source:HGNC Symbol;Acc:3585] |
| Location: | chr3 p25.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S330 | SKGRAsSSGNQ | HPRD | |
| S178 | PRLIVsQLKWL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S1435 | EEDEVsAGEKE | HPRD | |
| T1363 | PLLKKtLELLV | PhosphoSitePlus | |
| S1257 | GTAADsQQIHE | PhosphoSitePlus | |
| S594 | RSESPsLTQER | HPRD | |
| T1253 | KIEPGtAADSQ | PhosphoSitePlus | |
| T691 | LEEYDtQDGIA | PhosphoSitePlus; HPRD | |
| T1245 | AELEKtVKKIE | PhosphoSitePlus | |
| S1404 | IKSQNsQESTA | ATM | RegPhos |
| T596 | ESPSLtQERAN | Metal_resist | PhosphoSitePlus |
| S1423 | SQASKsKATED | HPRD | |
| S1401 | GEEIKsQNSQE | HPRD | |
| S1404 | IKSQNsQESTA | PhosphoSitePlus | |
| S1257 | GTAADsQQIHE | ATM | HPRD; phosphoELM; RegPhos |
| S1412 | STADEsEDDMS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S272 | MDKLSsIRLED | PhosphoSitePlus | |
| S594 | RSESPsLTQER | Metal_resist | PhosphoSitePlus |
| S590 | MAADRsESPSL | Metal_resist | PhosphoSitePlus |
| T596 | ESPSLtQERAN | HPRD; phosphoELM; RegPhos | |
| S271 | VMDKLsSIRLE | PhosphoSitePlus | |
| S222 | EILGDsQHADV | ATM | HPRD; phosphoELM; RegPhos |
| T1426 | SKSKAtEDGEE | HPRD | |
| S592 | ADRSEsPSLTQ | HPRD; phosphoELM; RegPhos; SysPTM | |
| T1408 | NSQEStADESE | PhosphoSitePlus | |
| S720 | VTSQEsGQKLV | HPRD | |
| S222 | EILGDsQHADV | MRE11A | HPRD |
| T608 | SDEQCtQVTSL | Metal_resist | PhosphoSitePlus |
| Y389 | MLFIIySTNTQ | PhosphoSitePlus | |
| Y458 | FGSLLyKYAFK | PhosphoSitePlus | |
| S592 | ADRSEsPSLTQ | Metal_resist | PhosphoSitePlus; SysPTM |
| S1423 | SQASKsKATEV | PhosphoSitePlus | |
| S201 | IMQLIsIAPEN | PhosphoSitePlus | |
| S8 | SKRRLsKSEDK | PhosphoSitePlus; HPRD; phosphoELM | |
| S1418 | EDDMSsQASKS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y684 | PVKALyGLEEY | PhosphoSitePlus | |
| S222 | EILGDsQHADV | PhosphoSitePlus | |
| S1401 | GEEIKsQNSQE | ATM | RegPhos |
| S331 | KGRASsSGNQE | PhosphoSitePlus | |
| S1407 | QNSQEsTADES | PhosphoSitePlus | |
| S167 | FENKNsDEINI | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S717 | GGPVTsQESGQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Dephosphorylation site |
| FACD2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000287647 | P679S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000398754 | S590R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000398754 | H1042Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000373317 | S590R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000373318 | S590R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000287647 | H1042Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000287647 | E650* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000399354 | *242S | COSMIC | Breast Cancer | 16959974 | ENSP00000287647 | Q1123* | COSMIC | Melanoma | ENSP00000373317 | H1042Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000373318 | H1042Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000398754 | E650* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000373318 | E650* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000287647 | S590R | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| FACD2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FACD2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | FACD2_HUMAN | kinase -> substrate | RegPhos |
| MRE11_HUMAN | FACD2_HUMAN | kinase -> substrate | HPRD |
| ATM_HUMAN | FACD2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03460 | Fanconi anemia pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007276 | gamete generation | IEA | biological_process |
| GO:0000793 | condensed chromosome | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0007129 | synapsis | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0010332 | response to gamma radiation | IDA | biological_process |
| GO:0006974 | response to DNA damage stimulus | IEA | biological_process |