Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DNLI4_HUMAN
Description:ligase IV, DNA, ATP-dependent [Source:HGNC Symbol;Acc:6601]
Location:chr13 q33.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y454KIKPEyVSGLMPhosphoSitePlus
T650KAPNLtNVNKIDNA-PKphosphoELM
S199LKLGVsQQTIFATMphosphoELM
T347FMQKGtKFDIKDNA_ligase_A_MPhosphoSitePlus
T650KAPNLtNVNKIPhosphoSitePlus
Y288KDGDVyKYFSRDNA_ligase_A_MPhosphoSitePlus
S358RMVEDsDLQTCDNA_ligase_A_MPhosphoSitePlus
T650KAPNLtNVNKIPRKDCHPRD

Dephosphorylation site
DNLI4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385955D597YCOSMICOvarian Cancer21720365
ENSP00000349393P492LCOSMICOvarian Cancer21720365
ENSP00000402030I259VCOSMICHead and Neck Cancer21798893
ENSP00000349393D597YCOSMICOvarian Cancer21720365
ENSP00000402030D597YCOSMICOvarian Cancer21720365
ENSP00000385955S292FCOSMICSkin Cancer21984974
ENSP00000385955P492LCOSMICOvarian Cancer21720365
ENSP00000349393R101TCOSMICHead and Neck Cancer21798893
ENSP00000385955R101TCOSMICHead and Neck Cancer21798893
ENSP00000349393I259VCOSMICHead and Neck Cancer21798893
ENSP00000402030R101TCOSMICHead and Neck Cancer21798893
ENSP00000402030S292FCOSMICSkin Cancer21984974
ENSP00000385955I259VCOSMICHead and Neck Cancer21798893
ENSP00000349393S292FCOSMICSkin Cancer21984974
ENSP00000402030P492LCOSMICOvarian Cancer21720365

Differential expressed protein
DNLI4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DNLI4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANDNLI4_HUMANkinase -> substrateRegPhos
PRKDC_HUMANDNLI4_HUMANkinase -> substrateHPRD
ATM_HUMANDNLI4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03450Non-homologous end-joining

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003910DNA ligase (ATP) activityIEAmolecular_function
GO:0000012single strand break repairIDAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0035019somatic stem cell maintenanceISSbiological_process
GO:0048146positive regulation of fibroblast proliferationISSbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0051102DNA ligation involved in DNA recombinationISSbiological_process
GO:0032807DNA ligase IV complexIMPcellular_component
GO:0006297nucleotide-excision repair, DNA gap fillingIDAbiological_process
GO:0051276chromosome organizationIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0051103DNA ligation involved in DNA repairISSbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0051402neuron apoptotic processISSbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0016874ligase activityIDAmolecular_function
GO:0010165response to X-rayIMPbiological_process
GO:0051402neuron apoptotic processIEAbiological_process
GO:0045190isotype switchingISSbiological_process
GO:0006303double-strand break repair via nonhomologous end jIEAbiological_process
GO:0006266DNA ligationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003910DNA ligase (ATP) activityIDAmolecular_function
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0033151V(D)J recombinationIDAbiological_process
GO:0003909DNA ligase activityIDAmolecular_function
GO:0006273lagging strand elongationIBAbiological_process
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexISScellular_component
GO:0003677DNA bindingIDAmolecular_function
GO:0010212response to ionizing radiationIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIEAcellular_component
GO:0010332response to gamma radiationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0000793condensed chromosomeIDAcellular_component
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0045190isotype switchingIEAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0008283cell proliferationISSbiological_process
GO:0006303double-strand break repair via nonhomologous end jIDAbiological_process
GO:0051102DNA ligation involved in DNA recombinationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0008283cell proliferationIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0051301cell divisionIEAbiological_process
GO:0001701in utero embryonic developmentISSbiological_process
GO:0006302double-strand break repairISSbiological_process
GO:0007417central nervous system developmentISSbiological_process
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:0050769positive regulation of neurogenesisIEAbiological_process
GO:0051103DNA ligation involved in DNA repairIEAbiological_process
GO:0033153T cell receptor V(D)J recombinationIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0033151V(D)J recombinationIEAbiological_process
GO:0002328pro-B cell differentiationISSbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0033152immunoglobulin V(D)J recombinationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0070419nonhomologous end joining complexIDAcellular_component
GO:0006310DNA recombinationIEAbiological_process
GO:0051276chromosome organizationISSbiological_process
GO:0010332response to gamma radiationISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0050769positive regulation of neurogenesisISSbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0033153T cell receptor V(D)J recombinationISSbiological_process
GO:0002328pro-B cell differentiationIEAbiological_process
GO:0006266DNA ligationIDAbiological_process
GO:0071285cellular response to lithium ionIEAbiological_process