| UniProt/SwissProt ID: | H2AX_HUMAN |
| Description: | H2A histone family, member X [Source:HGNC Symbol;Acc:4739] |
| Location: | chr11 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T137 | GGKKAtQASQE | PhosphoSitePlus; RegPhos | |
| T121 | LLPKKtSATVG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S2 | RGKT | HPRD | |
| S2 | MSGRGkT | RegPhos | |
| S140 | KATQAsQEY | ATR | RegPhos |
| S140 | KATQAsQEY | ATM | RegPhos |
| T137 | GGKKAtQASQ | HPRD | |
| S140 | KATQAsQ | ATM | HPRD; phosphoELM |
| T124 | KKTSAtVGPKA | PhosphoSitePlus; phosphoELM; RegPhos | |
| S140 | KATQAsQEY__ | PhosphoSitePlus | |
| Y40 | LRKGHyAERVG | Histone | PhosphoSitePlus |
| T102 | LLGGVtIAQGG | PhosphoSitePlus | |
| S140 | KATQAsQ | phosphoELM | |
| S140 | KATQAsQEY | DNAPK | RegPhos |
| S122 | LPKKTsATVGP | PhosphoSitePlus; HPRD | |
| Y143 | QASQEy_____ | PhosphoSitePlus | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S140 | GKKATQAsQEY | PPP1CA | HPRD |
| Mutation site |
| H2AX_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000364310 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 | ENSP00000364310 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S140 | GKKATQAsQEY____ | testicular cancer | 15846060 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ATR_HUMAN | H2AX_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | H2AX_HUMAN | kinase -> substrate | RegPhos |
| ATM_HUMAN | H2AX_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PP1A_HUMAN | H2AX_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05322 | Systemic lupus erythematosus |
| hsa05034 | Alcoholism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0000790 | nuclear chromatin | IEA | cellular_component |
| GO:0045739 | positive regulation of DNA repair | NAS | biological_process |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005657 | replication fork | IEA | cellular_component |
| GO:0007126 | meiosis | IEA | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006334 | nucleosome assembly | NAS | biological_process |
| GO:0000724 | double-strand break repair via homologous recombin | IEA | biological_process |
| GO:0000785 | chromatin | IEA | cellular_component |
| GO:0000786 | nucleosome | NAS | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0042393 | histone binding | IPI | molecular_function |
| GO:0005694 | chromosome | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0001673 | male germ cell nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006302 | double-strand break repair | NAS | biological_process |
| GO:0001741 | XY body | IEA | cellular_component |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0000724 | double-strand break repair via homologous recombin | TAS | biological_process |
| GO:0010212 | response to ionizing radiation | NAS | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0000077 | DNA damage checkpoint | IDA | biological_process |
| GO:0000794 | condensed nuclear chromosome | IEA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000781 | chromosome, telomeric region | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0003684 | damaged DNA binding | IEA | molecular_function |