| UniProt/SwissProt ID: | COM1_HUMAN |
| Description: | retinoblastoma binding protein 8 [Source:HGNC Symbol;Acc:9891] |
| Location: | chr18 q11.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S723 | RKMNDsLEDMF | PhosphoSitePlus; HPRD | |
| T450 | SKRKKtEEESE | PhosphoSitePlus | |
| S233 | YDQSQsPMAKA | PhosphoSitePlus | |
| S10 | GSSCGsPNSAD | PhosphoSitePlus | |
| S555 | PGEPCsQECII | PhosphoSitePlus | |
| S836 | KLASCsRHRFR | HPRD | |
| S17 | NSADTsSDFKD | PhosphoSitePlus | |
| S679 | DTKDGsQSKLG | PhosphoSitePlus; HPRD; phosphoELM | |
| S349 | TSLSPsLLQPG | PhosphoSitePlus | |
| Y522 | RQVTLyEALKT | PhosphoSitePlus | |
| S745 | LADSFsQAADE | PhosphoSitePlus | |
| T859 | VGFPStQTCME | PhosphoSitePlus | |
| S327 | PTRVSsPVFGA | PhosphoSitePlus; HPRD; phosphoELM | |
| T361 | KKHLKtLPFSN | PhosphoSitePlus | |
| S664 | PGADLsQYKMD | PhosphoSitePlus | |
| T315 | DSTSKtPPQEE | PhosphoSitePlus | |
| S18 | SADTSsDFKDL | PhosphoSitePlus | |
| S664 | PGADLsQYKMD | ATM | HPRD; phosphoELM |
| S326 | LPTRVsSPVFG | PhosphoSitePlus; HPRD | |
| T847 | YIPPNtPENFW | SAE2 | PhosphoSitePlus |
| S593 | LRPREsLETEN | PhosphoSitePlus | |
| S745 | LADSFsQAADE | ATM | HPRD; phosphoELM |
| Dephosphorylation site |
| COM1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000382628 | K337E | OMIM | Pancreatic Cancer | 9811458 | ENSP00000382628 | E320K | COSMIC | Melanoma | ENSP00000323050 | K337E | OMIM | Pancreatic Cancer | 9811458 | ENSP00000323050 | S696N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000323050 | K355E | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000382628 | S696N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000382628 | S276N | COSMIC | Lung Cancer | 20668451 | ENSP00000323050 | E320K | COSMIC | Melanoma | ENSP00000323050 | S276N | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| COM1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| COM1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | COM1_HUMAN | kinase -> substrate | RegPhos |
| ATM_HUMAN | COM1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| COM1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031572 | G2/M transition DNA damage checkpoint | IDA | biological_process |
| GO:0017053 | transcriptional repressor complex | IDA | cellular_component |
| GO:0001103 | RNA polymerase II repressing transcription factor | IPI | molecular_function |
| GO:0007126 | meiosis | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0000724 | double-strand break repair via homologous recombin | IDA | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0010792 | DNA double-strand break processing involved in rep | IMP | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0003684 | damaged DNA binding | IDA | molecular_function |
| GO:0001106 | RNA polymerase II transcription corepressor activi | IDA | molecular_function |
| GO:0001835 | blastocyst hatching | IEA | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0000014 | single-stranded DNA specific endodeoxyribonuclease | IMP | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |