Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:COM1_HUMAN
Description:retinoblastoma binding protein 8 [Source:HGNC Symbol;Acc:9891]
Location:chr18 q11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S723RKMNDsLEDMFPhosphoSitePlus; HPRD
T450SKRKKtEEESEPhosphoSitePlus
S233YDQSQsPMAKAPhosphoSitePlus
S10GSSCGsPNSADPhosphoSitePlus
S555PGEPCsQECIIPhosphoSitePlus
S836KLASCsRHRFRHPRD
S17NSADTsSDFKDPhosphoSitePlus
S679DTKDGsQSKLGPhosphoSitePlus; HPRD; phosphoELM
S349TSLSPsLLQPGPhosphoSitePlus
Y522RQVTLyEALKTPhosphoSitePlus
S745LADSFsQAADEPhosphoSitePlus
T859VGFPStQTCMEPhosphoSitePlus
S327PTRVSsPVFGAPhosphoSitePlus; HPRD; phosphoELM
T361KKHLKtLPFSNPhosphoSitePlus
S664PGADLsQYKMDPhosphoSitePlus
T315DSTSKtPPQEEPhosphoSitePlus
S18SADTSsDFKDLPhosphoSitePlus
S664PGADLsQYKMDATMHPRD; phosphoELM
S326LPTRVsSPVFGPhosphoSitePlus; HPRD
T847YIPPNtPENFWSAE2PhosphoSitePlus
S593LRPREsLETENPhosphoSitePlus
S745LADSFsQAADEATMHPRD; phosphoELM

Dephosphorylation site
COM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000382628K337EOMIMPancreatic Cancer9811458
ENSP00000382628E320KCOSMICMelanoma
ENSP00000323050K337EOMIMPancreatic Cancer9811458
ENSP00000323050S696NCOSMICOvarian Cancer21720365
ENSP00000323050K355EBIOMARTBrain Cancer21930507, 21930502
ENSP00000382628S696NCOSMICOvarian Cancer21720365
ENSP00000382628S276NCOSMICLung Cancer20668451
ENSP00000323050E320KCOSMICMelanoma
ENSP00000323050S276NCOSMICLung Cancer20668451

Differential expressed protein
COM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
COM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCOM1_HUMANkinase -> substrateRegPhos
ATM_HUMANCOM1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
COM1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031572G2/M transition DNA damage checkpointIDAbiological_process
GO:0017053transcriptional repressor complexIDAcellular_component
GO:0001103RNA polymerase II repressing transcription factor IPImolecular_function
GO:0007126meiosisIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0000724double-strand break repair via homologous recombinIDAbiological_process
GO:0007067mitosisIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0010792DNA double-strand break processing involved in repIMPbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0003684damaged DNA bindingIDAmolecular_function
GO:0001106RNA polymerase II transcription corepressor activiIDAmolecular_function
GO:0001835blastocyst hatchingIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0000014single-stranded DNA specific endodeoxyribonucleaseIMPmolecular_function
GO:0005515protein bindingIPImolecular_function


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