Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAD50_HUMAN
Description:RAD50 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:9816]
Location:chr5 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T198RQVRQtQGQKVPhosphoSitePlus
T690QRVFQtEAELQHPRD; phosphoELM; RegPhos; SysPTM
S635FDVCGsQDFESPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1113MIVMRtTELVNPhosphoSitePlus
T536HTTTRtQMEMLHPRD
S237AQLTSsKEIVKRegPhos
T690QRVFQtEAELQRad50_zn_hookPhosphoSitePlus; SysPTM
S557IRKIKsRHSDEHPRD
Y1125DLDIYyKTLDQPhosphoSitePlus
S640SQDFEsDLDRLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S635FDVCGsQDFESATMphosphoELM; RegPhos; SysPTM
T1114IVMRTtELVNKPhosphoSitePlus
S560IKSRHsDELTSHPRD

Dephosphorylation site
RAD50_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265335A1248GTCGAOvarian Cancer21720365, 18772890
ENSP00000265335N494KBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265335Gastric CancerMetastasiscell lineDown0.5817022644
ENSP00000265335Breast CancerNormal vs. Cancercell lineUp3.317022634
ENSP00000265335Gastric CancerMetastasiscell lineDown0.5817022644

Hyperphosphorylation site
RAD50_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRAD50_HUMANkinase -> substrateRegPhos
ATM_HUMANRAD50_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03450Non-homologous end-joining
hsa03440Homologous recombination

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006281DNA repairIDAbiological_process
GO:0004003ATP-dependent DNA helicase activityIMPmolecular_function
GO:0007004telomere maintenance via telomeraseIDAbiological_process
GO:0000724double-strand break repair via homologous recombinTASbiological_process
GO:0032508DNA duplex unwindingIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0004518nuclease activityIEAmolecular_function
GO:0000784nuclear chromosome, telomeric regionIDAcellular_component
GO:0045120pronucleusIEAcellular_component
GO:0006310DNA recombinationIDAbiological_process
GO:0031954positive regulation of protein autophosphorylationIDAbiological_process
GO:0033674positive regulation of kinase activityIDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000723telomere maintenanceTASbiological_process
GO:0007131reciprocal meiotic recombinationTASbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0030674protein binding, bridgingIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0000014single-stranded DNA specific endodeoxyribonucleaseIDAmolecular_function
GO:0030870Mre11 complexIDAcellular_component
GO:0000019regulation of mitotic recombinationIDAbiological_process
GO:0006302double-strand break repairIMPbiological_process
GO:00084083'-5' exonuclease activityIDAmolecular_function


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